Can a gene need more than one knockout vector?

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Can a gene need more than one knockout vector?

2007-03-24 07:25:33 · 2 answers · asked by littlemin5 3 in Science & Mathematics ➔ Biology

2 answers

Possibly. In the eukaryote, genes occur on both sides of a chromosome, or on each pair. Therefore, if it is a dominant trait, both alleles will need to be knocked out it order to gain a mutant phenotype.

2007-03-24 07:32:37 · answer #1 · answered by Jacob Z 2 · 1⤊ 0⤋

Not really, selective breeding will accomplish this but it is doable with only one vector and exteme selection techniques in ES cells.

2007-03-24 14:35:10 · answer #2 · answered by rgomezam 3 · 0⤊ 0⤋