How are T cells sensitized?
direct exposure to antigen
or
presentation of an antigen by MHC 1 cells
2007-03-24 03:08:13 · 3 answers · asked by mrkittypong 5 in Science & Mathematics ➔ Biology
T Cells only recognize antigen that is presented by MHC. But remember that this can be MHC Class I (for CD8+ or cytotoxic T Cells) or MHC Class II (for CD4+ or helper T Cells). MHC class I is present on most cells of the body and presents intracellular antigen. MHC class II is present on antigen presenting cells or APC's (mostly macrophages and dendritic cells). Naiive T Cells must also be costimulated by a professional APC at the time of MHC/antigen presentation or anergy will result. This is an attempt to limit self-reactivity.
2007-03-24 05:44:39 · answer #1 · answered by Erik S 2 · 0⤊ 0⤋
presentation of an antigen by MHC 1 cells.
2007-03-24 10:51:04 · answer #2 · answered by EIU DUDE 3 · 0⤊ 0⤋
"Activation of naive T cells requires recognition of a foreign peptide fragment bound to a self major histocompatibility complex (MHC) marker molecule AND the simultaneous delivery of a co-stimulatory signal delivered by a specialized antigen-presenting cell. "
2007-03-24 11:57:50 · answer #3 · answered by tictactoe 2 · 0⤊ 0⤋