Why might an infection by Gram-negative bacteria be more difficult to treat than a Gram-positive bacteria.?

Answer 1

Gram-negative bacteria have a unique structure, the 'outer membrane'.

This membrane not only protects them from the dye in a Gram stain, but also from antibiotics and a variety of other treatments which would otherwise destroy the cell wall or inner membrane. This is also the structure that contains endotoxin in the bacteria.

Thus, the outer membrane not only makes the bacteria more dangerous to the host, but harder to kill as well.

Answer 2

Gram-negative Bacteria causes Endotoxemia

although antibiotics are effective for killing the bacteria, there is no effective means to stop the toxic effects of bacterial endotoxin once it has entered the bloodstream and begun its course of tissue inflammation.

A small amount of free endotoxin can be detoxified by the liver. When the detoxifying capacity of the liver is overcome, however, endotoxin remain in the blood.

If the body's defense system is overwhelmed by the multiplying bacteria endotoxin, then the immune responses "overreact" causing tissue destruction, endotoxic shock, and possibly death

Answer 3

on the cellular partitions of gram adverse micro organism are lippolysaccarides that are many times poisonous and there is an outer membrane that still helps those micro organism. on a similar time as the gram adverse would not have any outer membrane. This outer membrane impedes the get right of entry to of drugs like penicillin.