how was the codon cracked (DNA)?

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how was the codon cracked (DNA)?

2007-03-19 10:23:47 · 2 answers · asked by Anonymous in Science & Mathematics ➔ Biology

2 answers

In vitro using synthetic mRNA with different sequences. The first was UUU.... which codes for Phe.

The first elucidation of a codon was done by Marshall Nirenberg and Heinrich J. Matthaei in 1961 at the National Institutes of Health. They used a cell-free system to translate a poly-uracil RNA sequence (or UUUUU... in biochemical terms) and discovered that the polypeptide they had synthesized consisted of only the amino acid phenylalanine.

2007-03-19 13:46:19 · answer #1 · answered by gibbie99 4 · 0⤊ 0⤋

August 1999. I think around the University of Tennessee.

2007-03-19 17:27:32 · answer #2 · answered by ladyoftherrlake 3 · 0⤊ 0⤋