What do each of the 5 classes of immunoglobins recognize in human pathogenic defense?

Question

Please include as much specific information as possible, like what IgA recognizes, Igd recognizes, etc.

I am not asking about blood types or which types can mix...that's easier stuff my 7th grade friend. To be more specific, there are 5 main classes of antibodies, or immunoglobins, in your body's immune system. I'm looking for specific information regarding what each individual immunoglobin recognizes in an immune response.

Answer 1

are you asking about blood types (i.e. - A would be I^AI^A or I^Ai) and askign about transfusions and what specific blood types declien or the antibodies declien or wht they would accept? (for example - a could accept only A and O since it has antibodies against B and AB has B in it)
or is it somethign else please try to be more specific?

Answer 2

IgA
IgG
IgM
IgD
IgE

You will need a good immunology textbook to sort out their functions.

IgM is the first antibody produced in a humoral immune response - IgM is mainly found in the blood and less in the lymph.

IgG is the principle isotype in the blood and extracellular fluid.

IgA is the principle isotype in secretions, especially important in the gastrointestinal and respiratory tracts.

IgE is present at very low levels in blood or extracellular fluid.

IgD is poorly understood.

IgM activates complement. IgG1 is involved in opsonization., IgG3 activates complement. IgE sensitizes mast cells. IgA is involved in neutralization. Again, little is known about IgD.

Hope this helps. Best wishes.

Answer 3

I agree with what doctor said and just want to add that IgA is also found in breast milk and is believed to transfer certain humoral immunity to the nursing baby until its own immune system kicks into gear and this is one of the important reasons breastfeeding is considered superior to formula. Also, IgE is responsible for the allergic response and activates histamines. IgE is also thought to be active in asthma and other hyperimmune states.