What is the chance(%) of someone who is heterzygous for Huntington's Chorea passing the disease on to a child?

Answer 1

It is an autosomal (meaning it is not on a sex chromosome) dominant disorder, so a heterozygote (say Hh) has a 50% chance passing it on to a child.

Answer 2

Huntington's is autosomal dominant, isn't it? If the parent is heterozygous, does that not make them a sufferer of Huntington's? Wow, I hope you don't have that, it's a pretty horrible thing to have. Sorry. Well anyways, if you're heterozygous, there's a 50/50 chance of passing on the afflicted gene versus the non-afflicted. No way to tell which it will be, but you could always take the genetic screening route -- have testing of the amnionic fluid done, possibly have an abortion. Possibly some mode of IVF can arrange to avoid the afflicted gene? Or is that only science fiction right now? Boy I wish there was more stem cell research going on, then we might have a cure for this sort of thing!

Answer 3

As has been said, the chance of some one whom is heterozygous for Huntington' Chorea would be 50%. Huntington's is an autosomal dominant trait, meaning that only one copy of the affected allele is needed for offspring to affect them. Also as it is autosommal, it doesn't matter wheather the child is male or female.

So the chance of passing on the disease is 50%

Answer 4

As this disease is a rare example of a dominant genetic disorder then an affected individual can in theory have 2 possible genotypes +/hc or hc/hc - although the first one is much more common.

In the first case there is a 50% chance that they will pass on the hc allele and therefore the same chance that the child will inherit the disease. Obviously if they were homozygous for the condition then every child would be affected.

BTW it is more usual to refer to it as Huntingdon's disease these days.

Answer 5

nicely thinking extremly long term, in case you probably did have a toddler who had the ailment, you would be putting you, and your grandchildren by a large style of saddness in an prolonged time... in spite of this i might by no ability %. and decide, from a batch of my 'babys', for the suited one, i'm strange so i might subject approximately issues like, nicely if I chosen that different egg, possibly this does not have happened, or maybe that one might have been a extra clever determination etc lol.... i understand on the time they are not rather babys, yet that egg is your destiny toddler, in a completely a techniques obtainable way, it extremely is like picking which twin gets to stay and which one is thrown away.... And seeing the way it does no longer influence them until late in existence, as quickly as they have had the possibility to stay an prolonged wholesome existence, and function toddlers, and all that. i in my view have faith i might have my toddler certainly...

Answer 6

If I remember correctly, the genetic flaw is recessive and on an autosome, so the disease can arise only if both parents are carriers, and the odds are 25% in that case.

Answer 7

50%. Anyone with the gene will have the disease eventually, and will have a 50-50 chance of passing it on, unfortunately.

Answer 8

"HD is inherited as an autosomal dominant disorder with complete penetrance."
"Family history is the principal identified risk factor."

I'm sorry to say this, but autosomal dominant with complete penetrance means you have a 50% chance of passing it on.