Infertility is the inability to naturally conceive a child or to carry a pregnancy to full term. There are many reasons why a couple may not be able to conceive, or may not be able to conceive without medical assistance. (Note: although some aspects of this article may be generalizable, it deals primarily with infertility as pertains to human couples.)
Definition
Reproductive endocrinologists, the doctors specializing in infertility, consider a couple to be infertile if:
* the couple has not conceived after 12 months of unprotected intercourse if the female is under the age of 35
* the couple has not conceived after 6 months of unprotected intercourse if the female is over the age of 35 (declining egg quality of females over the age of 35 account for the age-based discrepency as when to seek medical intervention)
* the female is incapable of carrying a pregnancy to term.
Infertility affects approximately 10% of people of reproductive age [1] 15% of couples. Roughly 40% of cases involve a male contribution or factor, 40% involve a female factor, and the remainder involve both sexes. Healthy couples in their mid-20s having regular sex have a one-in-four chance of getting pregnant in any given month. This is called "Fecundity". There are some health insurance companies that cover diagnosis of infertility but frequently once diagnosed will not cover any treatment costs.
[edit] Causes
This section deals with unintentional causes of sterility. For more information about surgical techniques for preventing procreation, see sterilization.
[edit] Primary vs. secondary
According to the American Society for Reproductive Medicine, infertility affects about 6.1 million people in the U.S., equivalent to ten percent of the reproductive age population. Female infertility accounts for one third of infertility cases, male infertility for another third, combined male and female infertility for another 15%, and the remainder of cases are "unexplained"[2].
A Robertsonian translocation in either partner may cause recurrent abortions or complete infertility.
"Secondary infertility" is difficulty conceiving after already having conceived and carried a normal pregnancy. Apart from various medical conditions (e.g. hormonal), this may come as a result of age and stress felt to provide a sibling for their first child. Technically, secondary infertility is not present if there has been a change of partners.
Some women are infertile because their ovaries do not mature and release eggs. In this case synthetic FSH can be given as injections to stimulate eggs to mature in the ovaries.
[edit] Female infertility
Factors relating to female infertility are:
* General factors
o Diabetes mellitus, thyroid disorders, adrenal disease
o Significant liver, kidney disease
* Hypothalamic-pituitary factors:
o Kallmann syndrome
o Hypothalamic dysfunction
o Hyperprolactinemia
o Hypopituitarism
* Ovarian factors
o Polycystic ovarian syndrome
o Anovulation
o Diminished ovarian reserve
o Luteal dysfunction
o Premature menopause
o Gonadal dysgenesis (Turner syndrome)
o Ovarian neoplasm
* Tubal/peritoneal factors
o Endometriosis
o Pelvic adhesions
o Pelvic inflammatory disease (PID, usually due to chlamydia)
o Tubal occlusion
o Tubal dysfunction
* Uterine factors
o Uterine malformations
o Uterine fibroids (leiomyoma)
o Asherman's Syndrome
* Cervical factors
o Cervical stenosis
o Antisperm antibodies
o Insufficient cervical mucus (for the travel and survival of sperm)
* Vaginal factors
o Vaginismus
o Vaginal obstruction
* Genetic factors
o Various intersexed conditions, such as androgen insensitivity syndrome
[edit] Male infertility
Factors relating to male infertility include[3]:
* Pretesticular causes
o Endocrine problems, i.e. diabetes mellitus, thyroid disorders
o Hypothalamic disorders, i.e. Kallmann syndrome
o Hyperprolactinemia
o Hypopituitarism
o Hypogonadism due to various causes
o Drugs, alcohol
* Testicular factors
o Genetic defects on the Y chromosome
+ Y chromosome microdeletions
o Abnormal set of chromosomes
+ Klinefelter syndrome
o Neoplasm, e.g. seminoma
o Idiopathic failure
o Cryptorchidism
o Varicocele
o Trauma
o Hydrocele
o Mumps
o Testicular dysgenesis syndrome
* Posttesticular causes
o Vas deferens obstruction
o Infection, e.g. prostatitis
o Retrograde ejaculation
o Hypospadias
o Impotence
o Acrosomal defect/egg penetration defect
* Smoking
o According to a study conducted by the American Society for Reproductive Medicine, smoking is one the most prominent factors contributing to low sperm count in men.[citation needed]
Some causes of male infertility can be determined by analysis of the ejaculate, which contains the sperm. The analysis includes counting the number of sperm and measuring their motility under a microscope:
* Producing few sperm, oligospermia, or no sperm, azoospermia.
* A sample of sperm that is normal in number but shows poor motility, or asthenozoospermia.
In the majority of cases of male infertility and low sperm quality, no clear cause can be identified with current diagnostic methods. It has been speculated that random mutations of the Y chromosome may be an important factor. As the human Y chromosome is passed directly from father to son, it is not protected against accumulating copying errors, whereas other chromosomes are error corrected by recombining genetic information from mother and father. This may leave natural selection as the primary repair mechanism for the Y chromosome. Microdeletions in the Y chromosome have been found at a much higher rate in infertile men than in fertile controls and the correlation found may still go up as improved genetic testing techniques for the Y chromosome are developed. (Existing test kits for Y chromosome microdeletions with PCR markers cover only a tiny fraction of the chromosome's 23 million base pairs and therefore very likely still miss most mutations. The gold standard test for genetic mutation, namely complete DNA sequencing of a patient's Y chromosome, is still far too expensive for use in epidemiologic research or even clinical diagnostics.)
[edit] Combined infertility
In some cases, both the man and woman may be infertile or sub-fertile, and the couple's infertility arises from the combination of these conditions. In other cases, the cause is suspected to be immunological or genetic; it may be that each partner is independently fertile but the couple cannot conceive together without assistance.
[edit] Unexplained infertility
In about 15% of cases the infertility investigation will show no abnormalities. In these cases abnormalities are likely to be present but not detected by current methods. Possible problems could be that the egg is not released at the optimum time for fertilization, that it may not enter the fallopian tube, sperm may not be able to reach the egg, fertilization may fail to occur, transport of the zygote may be disturbed, or implantation fails. It is increasingly recognized that egg quality is of critical importance and women of advanced maternal age have eggs of reduced capacity for normal and successful fertilization.
2007-03-06 20:55:55
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answer #1
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answered by Anonymous
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Infertility means difficulty in becoming pregnant (conceiving) despite having regular sex when not using contraception. There is no definite cut-off point to say when a couple is infertile. Many couples take several months to conceive. About 84 couples out of 100 conceive within a year of trying. About 92 couples out of 100 conceive within two years. Looking at this another way, about 1 in 7 couples do not conceive within a year of trying. However, more than half of these couples will conceive over the following year, without any treatment.
Doctors usually suggest some tests if a couple have not conceived after one year, despite regular sexual intercourse. After two years, treatment may be considered. Tests or treatment may start earlier if the woman is older, or if there is an obvious reason why a particular couple will not conceive, however long they try.
It is usually worth seeing a GP if you have not conceived after one year of trying. A GP can check for some common causes, talk things over and discuss possible options. You may want to see your GP earlier, if the woman in the couple is over the age of 36 or if either partner has a history of fertility problems.
2016-09-01 23:09:47
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answer #2
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answered by malar 2
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Infertility may be due to a single cause in either you or your partner, or a combination of factors that may prevent a pregnancy from occurring or continuing. Fortunately, there are many safe and effective therapies for overcoming infertility. These treatments significantly improve the chances of becoming pregnant.
2015-01-18 19:58:28
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answer #3
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answered by Anjana 3
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Bringing Hope to Infertile Couples
http://bit.ly/1M1ffxU
2015-03-01 17:54:51
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answer #4
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answered by Anjali 3
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In our society people blame to the for infertility but in science both man and woman are equally responsible for it. Bacterial infections may begin around the uterus and spread to other reproductive organs, resulting in infertility. Fibroids in the uterus are indicative of infertility. Tumors in the cervix often cause stenosis, or narrowing of the cervix, which is a common indicator of infertility.
2015-05-11 00:05:58
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answer #5
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answered by NAZU 2
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Infertility--The Treatments, the Questions :
- A Baby Boom Through Assisted Reproduction
- The Choices, the Issues
http://www.watchtower.org/e/20040922/article_01.htm
2007-03-06 21:38:40
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answer #6
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answered by Anonymous
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Infertility is the inability of couples to conceive clinical pregnancy after one year or more of trying or, for women aged 35 years older, after six months of trying to conceive (CDC.gov). The CDC states that infertility may be caused by a variety of factors including genetic abnormalities, aging, acute and chronic diseases, treatments for certain conditions, behavioral factors, and exposure to environmental, occupational and infectious agents.
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2015-05-10 10:56:52
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answer #7
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answered by infertiltyandheal 1
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talk to the specialist who will have more details on your partners history / symptoms etc..
often people are just unable to have children - as harsh as that sounds, and maybe you need to think about adoption / fostering,
2007-03-06 20:43:26
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answer #8
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answered by schmushe 6
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hmmmmmmmm
2007-03-06 20:59:16
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answer #9
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answered by john k 2
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