how much ibuprofen does it take to kill you?

Question

i'm NOT going to overdose or any thng, but i was just wondering how much it would take...? any one know how many mg's?
thanx!
*:+:* loVely *:+:*

Answer 1

It is not possible to determine the precise lethal dose. See the excerpt from the following article from Wikipedia:

Ibuprofen overdose has become common since it was licensed for over-the-counter use. There are many overdose experiences reported in the medical literature.[9] Human response in cases of overdose ranges from absence of symptoms to fatal outcome in spite of intensive care treatment. Most symptoms are an excess of the pharmacological action of ibuprofen and include abdominal pain, nausea, vomiting, drowsiness, dizziness, headache, tinnitus, and nystagmus. Rarely more severe symptoms such as gastrointestinal bleeding, seizures, metabolic acidosis, hyperkalaemia, hypotension, bradycardia, tachycardia, atrial fibrillation, coma, hepatic dysfunction, acute renal failure, cyanosis, respiratory depression, and cardiac arrest have been reported.[10]. The severity of symptoms varies with the ingested dose and the time elapsed, however, individual sensitivity also plays an important role. Generally, the symptoms observed with an overdose of ibuprofen are similar to the symptoms caused by overdoses of other NSAIDs.

There is little correlation between severity of symptoms and measured ibuprofen plasma levels. Toxic effects are unlikely at doses below 100 mg/kg but can be severe above 400 mg/kg;[11] however, large doses do not indicate that the clinical course is likely to be lethal.[12] It is not possible to determine a precise lethal dose, as this may vary with age, weight, and concomitant diseases of the individual patient.

Therapy is largely symptomatic. In cases presenting early, gastric decontamination is recommended. This is achieved using activated charcoal; charcoal absorbs the drug before it can enter the systemic circulation. Gastric lavage is now rarely used, but can be considered if the amount ingested is potentially life threatening and it can be performed within 60 minutes of ingestion. Emesis is not recommended.[13] The majority of ibuprofen ingestions produce only mild effects and the management of overdose is straightforward. Standard measures to maintain normal urine output should be instituted and renal function monitored.[11] Since ibuprofen has acidic properties and is also excreted in the urine, forced alkaline diuresis is theoretically beneficial. However, due to the fact ibuprofen is highly protein bound in the blood, there is minimal renal excretion of unchanged drug. Forced alkaline diuresis is therefore of limited benefit.[14] Symptomatic therapy for hypotension, GI bleeding, acidosis, and renal toxicity may be indicated. Occasionally, close monitoring in an intensive care unit for several days is necessary. If a patient survives the acute intoxication, he/she will usually experience no late sequelae

Answer 2

Lots more than you can keep down w/o throwing up. I take a lot of it for a painful muscle condition and it just makes me sick if I take too much. You might give yourself an ulcer but I don't think you could keep enough down to die. Call Dr Kavorkian for other suggestions. No, just kidding. If you just tell yourself, " this too shall pass," you can make it day by day and everything gets better. If you off yourself, you'd never get to find out how much fun you are missing out on the next day. Good Luck

Answer 3

Then WHY would you ask such a thing? Who cares?

There is no set overdose amount. Everyone reacts differently to medication. What wouldn't hurt one person, would kill another. At the very least, you'd ruin your liver and kidneys and have to be hooked up to a dialysis machine for the rest of your life. And your life wouldn't be that long anymore.

Answer 4

Depends on the dose?
but don;t take more then a total of 8 in a 24 hour period i guess any more then that could harm you

remember Jesus loves you he is the answer to everything talk to him out loud or in your mind he hears you!!!

Answer 5

I dont feel safe answering that.

Answer 6

NO way would I tell you that.
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