Louis Pasteur Quick Facts
French chemist and biologist
Birth December 27, 1822
Death September 28, 1895
Place of Birth Dole, France
Known for Founding microbiology
Proposing the germ theory of disease, in which diseases arise from naturally existing microorganisms, not from spontaneous generation, the supposed formation of disease-causing organisms from nonliving matter
Inventing the process of pasteurization
Developing a vaccine for rabies
Career 1848 Taught physics at Dijon
1849 Taught physics at the University of Strasbourg
1854-57 Taught chemistry, and was dean of sciences, at the University of Lille
1857-67 Served as director of Scientific Studies at the Ãcole Normal Supérieure
1863-68 Taught chemistry, geology, and physics at the Ãcole des Beaux-Arts
1888 Became director of the Institut Pasteur in Paris, which was created to further his research
Did You Know Pasteur first tried his experimental rabies vaccine on a nine-year-old boy bitten by a rabid dog. The boy, who would likely have died otherwise, survived.
Pasteur saved France's silk industry from disaster when he discovered that some silkworms were infected with a disease-causing microorganism, and recommended that those infected be destroyed.
2007-02-21 20:21:34
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answer #2
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answered by troubleshooter 1
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Louis Pasteur (December 27, 1822 – September 28, 1895) was a French microbiologist and chemist. His experiments confirmed the germ theory of disease, and he created the first vaccine for rabies. He is best known to the general public for showing how to stop milk and wine from going sour - this process came to be called pasteurization. He is regarded as one of the three main founders of bacteriology, among Ferdinand Cohn and Robert Koch. He also made many discoveries in the field of chemistry, most notably the asymmetry of crystals.
Pasteur's later work on diseases included work on chicken cholera. During this work, a culture of the responsible bacteria had spoiled and failed to induce the disease in some chickens he was infecting with the disease. Upon reusing these healthy chickens, Pasteur discovered that he could not infect them, even with fresh bacteria; the weakened bacteria had caused the chickens to become immune to the disease, even though they had only caused mild symptoms.
This discovery was serendipitous. His assistant Charles Chamberland (of french origin) had been instructed to inoculate the chickens after Pasteur went on holiday. Chamberland failed to do this, but instead went on holiday himself. On his return, the month old cultures made the chickens unwell, but instead of the infection being fatal, as usual, the chickens recovered completely. Chamberland assumed an error had been made, and wanted to discard the apparently faulty culture when Pasteur stopped him. Pasteur guessed the recovered animals now might be immune to the disease, as were the animals at Eure-et-Loir that had recovered from anthrax.
In the 1870s, he applied this immunization method to anthrax, which affected cattle, and aroused interest in combating other diseases.
Louis Pasteur in his laboratory, painting by A. Edelfeldt in 1885.Pasteur publicly claimed he had made the anthrax vaccine by exposing the bacillus to oxygen. His laboratory notebooks, now in the Bibliotheque Nationale in Paris, in fact show Pasteur used the method of rival Jean-Joseph-Henri Toussaint, a Toulouse veterinary surgeon, to create the anthrax vaccine [1] [2]. This method used the oxidizing agent potassium dichromate. Pasteur's oxygen method did eventually produce a vaccine but only after he had been awarded a patent on the production of an anthrax vaccine.
The notion of a weak form of a disease causing immunity to the virulent version was not new; this had been known for a long time for smallpox. Inoculation with smallpox was known to result in far less scarring, and greatly reduced mortality, in comparison to the naturally acquired disease. Edward Jenner had also discovered vaccination, using cowpox to give cross-immunity to smallpox (in 1796), and by Pasteur's time this had generally replaced the use of actual smallpox material in inoculation. The difference between smallpox vaccination and cholera and anthrax vaccination was that the weakened form of the latter two disease organisms had been generated artificially, and so a naturally weak form of the disease organism did not need to be found.
This discovery revolutionized work in infectious diseases, and Pasteur gave these artificially weakened diseases the generic name of vaccines, to honour Jenner's discovery. Pasteur produced the first vaccine for rabies by growing the virus in rabbits, and then weakening it by drying the affected nerve tissue.
The rabies vaccine was initially created by Emile Roux, a French doctor and a colleague of Pasteur who had been working with a killed vaccine produced by desiccating the spinal cords of infected rabbits. The vaccine had only been tested on eleven dogs before its first human trial.
This vaccine was first used on 9-year old Joseph Meister, on July 6, 1885, after the boy was badly mauled by a rabid dog. This was done at some personal risk for Pasteur, since he was not a licensed physician and could have faced prosecution for treating the boy. However, left without treatment, the boy faced almost certain death from rabies. After consulting with colleagues, Pasteur decided to go ahead with the treatment. Fortunately, the treatment proved to be a spectacular success, with Meister avoiding the disease; thus, Pasteur was hailed as a hero and the legal matter was not pursued. The treatment's success laid the foundations for the manufacture of many other vaccines. The first of the Pasteur Institutes was also built on the basis of this achievement.
2007-02-21 20:19:26
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answer #3
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answered by cubcowboysgirl 5
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