What should i ask ?

Question

if you had to ask your friend what they didnt like about you
then what would be some of the questions ?
example - do you like it when im immature ?

Answer 1

I would ask these questions:
Do you like it when I don't listen?
Do you like it when I am at my most obnoxious times?
Do you like it when I am really annoying?
Do you not like what I don't like cause then I would like it right?
DO YOU LIKE IT WHEN I ASK ANNOYING AND DISTURBING QUESTIONS?

Answer 2

Nuclei removed from mouse brain tumor
cells and transplanted into mouse eggs whose own nuclei have been
removed, give rise to cloned embryos with normal tissues, even though
the mutations causing the cancer are still present. This research, from
scientists at St. Jude Children's Research Hospital, appears in the
June 1 issue of Cancer Research.

The finding demonstrates that the cancerous state can be reversed by
reprogramming the genetic material underlying the cancer, according to
James Morgan, Ph.D., a member of the St. Jude Department of
Developmental Neurobiology, and lead author of the study. The findings
also indicate that genetic mutations alone are not always sufficient to
cause a cell to become cancerous.

“Specifically, it shows that so-called epigenetic factors are key
elements in the development and maintenance of tumors,” Morgan said.

Epigenetic factors are those that influence the cell’s behavior.
Examples include environmental effects and chemical modification.

“The concept of epigenetic factors having a role in cancer is already
largely accepted,” Morgan said. “In fact, it’s already known that
epigenetic alterations of chromosomes can cause certain rare forms of
cancer. And some anti-cancer agents actually target epigenetic changes.
But this is the first formal proof of the theory in a living animal.”

Unlike mutations, epigenetic modifications of DNA are potentially
reversible molecular events that cause changes in gene expression. Some
genes that help prevent the development of cancer (e.g., tumor
suppressor genes) can be targets of epigenetic factors. The
inactivation of such a gene might make the DNA more vulnerable to
developing a cancer-causing mutation.

The St. Jude researchers used nuclei from mouse medulloblastoma cells
to create the clones. Medulloblastomas are brain tumors that tend to
spread to the spinal cord. They account for about 20 percent of
childhood brain tumors and most often occur in children under ten years
of age.

The team, led by Morgan and department chair Tom Curran, Ph.D., placed
nuclei from medulloblastoma cells into mouse eggs whose own DNA had
been removed.

“Since the embryos did not develop tumors, we conclude that the
cancerous properties were removed by reprogramming,” Morgan said.

“The use of mouse eggs to reprogram cancer cell DNA represents a new
strategy for investigating the molecular basis of cancer,” Curran said.
“By studying this model we hope to identify which epigenetic factors
may contribute to this form of brain tumor. In addition, it also gives
us a valuable tool for testing new therapies.”

Other authors of the study include Leyi Li, Michele Connelly and
Cynthia Wetmore.

### This work was supported in part by a National Institute of Health
(NIH) Cancer Center Support CORE grant, ALSAC, the Pediatric Brain
Tumor Foundation and NIH grants.

St Jude Children's Research Hospital is internationally recognized for
its pioneering work in finding cures and saving children with cancer
and other catastrophic diseases. Founded by late entertainer Danny
Thomas and based in Memphis, Tenn., St. Jude freely shares its
discoveries with scientific and medical communities around the world.
No family ever pays for treatments not covered by insurance, and
families without insurance are never asked to pay. St. Jude is
financially supported by ALSAC, its fund-raising organization.

Answer 3

The only way to know this is just to go up and ask them..

Answer 4

Don't be specific; generalize the question and ask, "Is there anything you don't like about me?"

Answer 5

I am sorry but we can not give you answeres that your friends would. We don't know you.. Ask them

Answer 6

when i get on a serious level with u, do i sometimes get on your nerve's

Answer 7

What annoys you about me?