"a crack-enhanced Kathie Lee Gifford. " What does this phrase mean?

Question

(From "How to lose a guy in 10 days" dialogue)

Oh, she was. That was the good Andie, guys.
This amazing, fun, cool, sexy woman. I'm talking about the evil Andie, now.
It's like a crack-enhanced Kathie Lee Gifford.

She's probably bipolar.

Answer 1

It probably means that she's acting like a hyper, needy, spazy, crazy lady! Kathie Lee is already like this, so in crack WOW!