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is this an example of a nonsense frameshift mutation if the nucleotide 25 (G) in the DNA template is deleted?

dna template:
3' aattcgttcttctacgtagctctcgattgcgagatcagaaaagttttttgacttttatgcat 5'

mRNA transcript:

5' uuaagcaagaagaugcaucgagaccuaacgcucuagucuuuucaaaaaacugaaaauacgua 3'

amino acids:

leucine, serine, lysine, lysine, methionine, histidine, arginine, aspartic acid, leucine,threonine, leucine, stop codon, serine, phenylalanine, glutamine, lysine, threonine, glutamic acid, asparganine, threonine


with 25 (G) deleted

5' uuaagcaagaagaugcaucgaaccuaacgcucuagucuuuucaaaaaacugaaaauacgua 3'

amino acids:

leucine, serine, lysine, lysine, methionine, histidine, arginine, threonine, stop codon, arginine, serine, serine, leucine, phenylalaline, lysine, lysine, leucine, isoleucine, glycine

2007-02-19 04:08:18 · 1 answers · asked by Cynthia P 1 in Science & Mathematics Biology

1 answers

The change in the sequence is before the stop-codon, so this will lead to a "false" protein sequence, as the deletion leads to a different amino acid sequence.

If it had occured after the stop-codon, it would probably not be a nonsense mutation.

2007-02-19 04:22:29 · answer #1 · answered by Dr. Zaius 4 · 0 0

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