What would happen to the protein if a base pair substitution occured at the tenth base, where G in the teplate

Question

strand suddenly mutated to an A(adenosine)??

Answer 1

`the protein sequence would most certainly end up mutated.
If the mutation happen at the 10th base, this would correspond to the first base of a codon. Now, for the Wobble Theory (see link), the tRNA is quite flexible to mutations tht happen to the last base of the codon and (to some extent) to the one in the middle. This is most polymorphisms occur. However, when it's the first position to be affected, this most offen results in an aminoacid change in the protein structure.
If the new aminoacid share a similar polarity with the previous aa, then it is likely that the overall structure and function wold not be changed and the mutation would be silent (at least phenotypically); however, if a polar aa substitutes for a non-polar one (or vice versa) then the result would be a disruption of the structure and function of the polypeptide.

Answer 2

1

Answer 3

It depends on two things. First it is possible a base pair substitution does nothing to change the amino acid sequence of the peptide. The codons UCU, UCC, UCA, UCG, AGU and AGC all code for the amino acid, Serine.

If there is an amino acid change, the next question is, "Does the change affect the structure or function of the peptide?" An amino acid change may do nothing at all, or it may destroy function of that peptide entirely. There are also conservative changes in which an amino acid is substituted for a similiar one, for instance a Serine for a Threonine. Since both of these amino acids have similiar side chains, there may be little to no change in the function of the resulting peptide.

So the answer to your question is that it depends on both the particular nucleotide change and the amino acid change if there is one.

Answer 4

Okay your question is worded kind of funny, but I think I getcha. You are asking if there was a point mutation in the genes coding for a protein, what would happen. Proteins are utterly dependent on structure for function. So unless the mutation effected the structure, nothing should happen except you would have a slightly different chemical composition.