Just out of curiosity, people that suffer from hemophlia have problems with homeostasis.?

Question

I have also heard that hemophlia stems from families that intermarry.
e.g long ago kings and queens would marry closley related cousins, half brother or sister.
So does that also mean that it is a genetic issue as well?

Answer 1

When homeostasis is affected you get sick, any number of conditions including hemophilia will cause sickness from cancer to a simple sore throat. As for it being a genetic issue most likely but not 100% always. It can also be caused by any number of drugs{heparin, Aspirin overdose,Thienopyrindines, Coumadin etc}. Just about anything can be passed genetically but hemophilia is more common in males.

Answer 2

I think you mean hemostasis. Yes they have problems with this since clot formation is integral for maintaining the vasculature. Yes this is a genetic issue, since it is an X-linked disorder meaning it is inherited on the X chromosome. No hemophilia does not stem from families that intermarry, the disease allele is prevalent enough in the general population to make this not the norm for inheritance. Also, there are many different mutant alleles for the two genes that cause this disease and they can be spontaneous and not inherited from a parent. Yes inbreeding or consanguinity over successive generations in the same gene pool like the old kings and queens of europe can result in a higher frequency of offspring with recessive genetic disorders or at least keep the recessive disease allele in the gene pool. The family you are referring to is very famous indeed, so famous that the condition was once called royal hemophilia because of its occurance among the descendants of Britain's Queen Victoria, she was a carrier.

Answer 3

Your question is a bit confusing.

Hemophilia could be more common in families that intermarry because it is a recessive allele that isn't very common in the general population. People in families with hemophilia will have the allele more often than people in other families. Intermarriage would be a problem just as it is for other traits.

In the case of the royal families with hemophilia, it is commonly believed that Queen Victoria was the original source of the hemophilia and that she had a mutation for the hemophilia allele because the disorder was not in her family before her.

Hemophilia does not "stem" from families that intermarry. Hemophilia is a sex-linked (x-linked) recessive allele.