Question about Enzyme?

Question

An enzyme can only catalyze a reaction b/w very specific reactants due to their shapes. what might happen if the enzyme's shape was changed? Pls include at least one way to change the shape of an enzyme.

I'll give the best answer to the person who can answer well and it makes sense or not. Thanks!

Answer 1

Often times changing the shape of an enzyme will mess up its function.

Ways to change the "shape" of an enzyme include:
-->Make a deletion within the coding sequence: You might do this in a lab to look for active sites and this happens naturally in some instances for ex. CFTR is a protein that has a deletion which alters its activity and leads to cystic fibrosis

--> In vitro you can subject it to a variety of of treatments that will kill activity (heat and pH were mentioned above)

--> Sometimes the shape of an enzyme is held one way to keep it inactive until the body is ready to use it. Examples of this type often include phosphorylated enzymes where phosphorylation can either open or close the active site.

Probably many more examples but thos ewere the first things that came ot mind

have fun thinking about it!

Answer 2

Enzymes allow many chemical reactions to occur within an organism. Enzymes function as organic catalysts. A catalyst is a chemical involved in, but not changed by, a chemical reaction; therefore, enzymes should not typically change shape.

However; enzymes that work on glucose can change shape in order to facilitate the reaction necessary to release energy.

Answer 3

Heat and pH. Shape change would lead to no longer functioning as an enzyme. Enzymes are particular of their substrates, so fit is important, to say the least.

Answer 4

You could change the shape of an enzyme-substrate complex, addin a no competitive inhibitor. Also, incresing the acidity...


Look the source, it is a graphic example

Answer 5

You can bind the enzyme to another substrate to inactivate it and keep it from working.