Why are no large mammals poisonous to eat?

Question

Interestingly mammals have very rarely evolved poisonous tissue/blood to counter predation, whereas it is very common in insects and plants and exists to some degree in fish. Is there something that is preventing this from evolving or is it present to a lesser degree in mammals, as in some mammals taste bad etc. I feel there must be an evolutionary trade off to being a poisonous mammal for this not to have occurred, or that to distribute enough quick acting poison is probably impossible in large mammals. But even bad tasting or inedible flesh should be enough for predators to quickly learn not to prey on certain mammals. For instance if rabbits were as poisonous as a cane toad or at least inedible, what would stop rabbits from taking over the world (so to speak)?
That seems to point to me an important fact, that intraspecies competition is driving evolution more strongly than interspecies competition, also possibly digestive counter measures are evolving among predators in tandem

Answer 1

Cuban Solenodon (Atopogale cubana) & Haitian Solenodon (Solenodon paradoxus)
Solenodons look similar to big hedgehogs with no coat of spines. They both have venomous bites; the venom is delivered from modified salivary glands via grooves in their second lower incisors.

The calcaneous spur found on the male platypus's hind limb is used to deliver venom.Platypus (Ornithorhyncus anatinus)
Males have a venomous spur on their hind legs. Echidnas, the other monotremes, have spurs but no functional venom glands.
Eurasian water shrew (Neomys fodiens)
Capable of delivering a venomous bite.
Northern Short-tailed Shrew (Blarina brevicauda)
Capable of delivering a venomous bite.
Southern Short-tailed Shrew (Blarina carolinensis) & Elliot's Short-tailed Shrew (Blarina hylophaga)
Possibly have a venomous bite.

But you can see that it is the smaller, vulnerable ones that use this trick -- us big guys just use teeth -- and guns!

Answer 2

Basically, evolution is not based upon any goals.

If something develops poison, it's due to a precursor species developing it randomly due to genetic mutation and surviving because of it eg. toads with poisonous skin survived while those without it died out.

Mammals likely didn't evolve this way simply because they didn't happen to. If an opportunity doesn't arrise then it can't be acted upon.

Of course, this is only based on our current understanding of evolution/genetic development.

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Note: the person above me obviously missed the fact that you said "rarely" and not "never".