how mandrax (methaqualone) is isolated, identified and determined?

Answer 1

sorry, just have some infos


Methaqualone1 is a sedative drug.

It is similar in effect to barbiturates, a general CNS depressant. It was used in the 1960s and 1970s as an anxiolytic, for the treatment of insomnia, and as a sedative.

Usual effects include relaxation, euphoria, and drowsiness, also reducing heart rate and respiration. Larger doses can bring about depression, muscular miscoordination, and slurred speech.

An overdose can cause delirium, convulsions, hypertonia, hyperreflexia, vomiting, renal insufficiency, coma, and death through cardiac or respiratory arrest. It resembles barbiturate poisoning but with increased motor difficulties and a lower incidence of cardiac or respiratory depression. Toxicity is treated with diazepam and sometimes an anticonvulsant.

Methaqualone was discovered by the Indian researcher M. L. Gujiral in 1955 during an anti-malaria research program. It was marketed as a sleeping pill during the 1960s under a number of tradenames including Renoval and Melsed and in combination with an antihistamine as Mandrax. From 1965 it was sold on the U.S. market as Quaalude, Sopor and Parest; by 1972 it was the sixth most popular sedative in the US. The name Quaalude was apparently derived from the phrase 'quiet interlude' [citation needed] with an added 'aa' by the manufacturers in order to elicit a more positive public recognition, as was done with the drug Maalox. It was hoped that it was a 'safer' drug than barbiturates to use for sedation; however, it was found to have similar problems of tolerance and dependence.

Quaaludes became increasingly popular as a recreational drug during the 1960s. The drug was more tightly regulated in Britain under the Misuse of Drugs Act 1971 and in the US from 1973. With its addictive nature clear, it was withdrawn from many developed markets in the 1980s, being made a Schedule I drug in the US in 1984. Up until the fall of Nicolae Ceauşescu's regime in 1989, methaqualone (along with other sedatives) was used to pacify orphans in Romania's state-run orphanage system. Internationally, methaqualone is a Schedule II drug under the Convention on Psychotropic Substances. [1]

It is widely believed that the Church of Scientology was founded after a weekend-long Quaalude binge by its founders in the mid-1970's. In fact, one might theorize that part of the drug's placement on Schedule I was due to its role in the creation of this church. Despite the fact that 'ludes are almost impossible to obtain in the United States, Scientology is still around. Were it not for methaqualone, the Church of Scientology would not exist today.[citation needed]

Smoking methaqualone, either alone or as an adulterant added to various legal and illegal smoking mixtures, gained popularity in the United States during the mid 1970's. When smoked methaqualone gives the user an immediate trance-like euphoria that quickly wears off. Because the various binders and inert ingredients that were contained in the pill form were toxic when smoked, this practice was roundly decried by the medical community as a serious health risk. Smoking methaqualone quickly leads to emphysema and other chronic lung disorders.

Smoking marijuana laced with methaqualone has become a major problem in South Africa, rivalling crack cocaine as the most abused hard drug. Its low price (R30.00 average against R150.00 for crack) means it is the preferred hard drug of the large low-income section of society.

Answer 2

I pointed out as a feminist and agnostic whilst i became into 19, have not replaced that view in 30 years. yet I additionally became into very quiet and introverted till my 30's, when I have been given extra suitable, did no longer care what maximum persons concept anymore, and as a replace of being a quiet feminist, I became an outspoken feminist. I grew up in the previous abortion became into criminal, in the previous the pill became into severely disbursed, whilst there have been women persons's jobs and adult males's jobs, and you may desire to no longer stick to for the different gender's interest. I undergo in innovations whilst "in basic terms undesirable people have been raped, incest and baby molestation hardly if ever befell, and in basic terms unfavourable people have been batterers", or so it became into stated..... i might by no potential prefer to have lived in the previous feminists replaced our society.