what's the sickle cell trait ?

Question

my brother has sickle cell anemia. he's 26 i'm 23, is it true that i can carry the trait even though i don't have the disease, because we are so closely related?

Answer 1

Yes, you can have the allele for sickle cell. Having just one allele for sickle cell means a person has "sickle cell trait". You can read more about it at this site or many others on the web:

http://sickle.bwh.harvard.edu/sickle_trait.html

Sickle cell anemia means that a person has two alleles for sickle cell. If your brother has sickle cell anemia that means that he got one of these alleles from each of your parents. If your parents do not have sickle cell anemia, then they must be heterozygous (carriers).

In that case, you would have 1/2 or 50% chance of being a carrier, and your condition would be called sickle cell trait. You would have 1/4 or 25% chance of having no allele for sickle cell at all. You would have 1/4 or 25% chance of having sickle cell anemia.

Answer 2

Actually the guy above is incorrect - you don't have a 50% chance of being a carrier, you have a 66% chance of being a carrier. Since your brother has sickle-cell trait (we'll call that allele s), both your parents must be carriers (Ss). Their children could either be normal (SS, 25%), carrier (Ss or sS, 50%) or sickle-cell (ss, 25%). Since you are NOT ss, you must be one of the other options. In 2/3 of those cases, you are a carrier. Therefore, you're most likely a carrier. You can actually have this verified by simple blood test.

The sickle cell allele is quite common especially amongst people of West African descent, because it imparts a resistance to malaria on carriers of the trait. (Although people with two copies of the sickle cell allele, like your brother, end up with anemia.)

Answer 3

sickle cell anemia is when the RBCs are deformed and their ability to carry oxygen around the body is impaired.
it is a recessive trait. so both you parents must have carried the trait. say S is normal and s is sickle cell trait
then both parents would have had Ss. so the possible outcomes are SS, ss (sickle cell anemia) and Ss (carrier of the trait).
you may be healthy (SS) or carry the trait. if you carry the trait there is the possiblity that you can have achild with the trait (if the father also carries the trait).

Answer 4

Well,
The sickle cell trait would most likely run throughout your body as well even though you dont show any signs or symptoms.

Answer 5

It's possible, to determine that you would need to get a blood test. If you are a carrier then you probably have a few malformed blood cells, but nothing like the full blown disease.

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