discuss the MOA(mechanism of action) , characteristics and importance of the NA/K pump in biological system.?

Question

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Answer 1

Na+/K+-ATPase (also known as the Na+/K+ pump or sodium-potassium pump) is an enzyme located in the plasma membrane (specifically an electrogenic transmembrane ATPase). It is found in the plasma membrane of virtually every human cell and is common to all cellular life. It helps maintain cell potential and regulate cellular volume.

In order to maintain the cell potential, cells must keep a low concentration of sodium ions and high levels of potassium ions within the cell (intracellular). Outside cells (extracellular), there are high concentrations of sodium and low concentrations of potassium, so diffusion occurs through ion channels in the plasma membrane. In order to keep the appropriate concentrations, the sodium-potassium pump pumps sodium out and potassium in through active transport.

The mechanism is:

* The pump, with bound ATP, binds 3 intracellular Na+ ions.
* ATP is hydrolyzed, leading to phosphorylation of the pump at a highly conserved aspartate residue and subsequent release of ADP.
* A conformational change in the pump exposes the Na+ ions to the outside. The phosphorylated form of the pump has a low affinity for sodium ions, so they are released.
* The pump binds 2 extracellular K+ ions, leading to the dephosphorylation of the pump.
* ATP binds, and the pump reorients to release potassium ions inside the cell so the pump is ready to go again.

Answer 2

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