Will a change in the DNA sequence always affect enzyme activity?

Answer 1

not always because of several reason:
1)the change in Codon may resemble the original aminoacid!
2)the changes in Intron Sequences .

Answer 2

In addition to the previous answer about the redundant codon codes and intron sequences, there is a chance even if there is a dramatic amino acid change to the actual protein sequence of the enzyme. if the amino acid change doesn't affect the active site or entrance to the active site, the change may not matter much.

small groups like glycines won't change the form of the enzyme much, histidines may change the entire configuration because of the hydrophillic portions or hydrophobic portions.

Answer 3

No. A mutation at a internet site the place there is not any gene (ie, the place no transcription happens and no protein is synthesized) would be a silent mutation and undetectable phenotypically. The mutation finally ends up in differences interior the DNA sequences if : - it happens interior a gene - it happens on a promoter internet site (disrupting the expression the two by potential of silencing it, reducing it or increasing it) - it happens on an enhancer (might impact the expression ranges, besides the undeniable fact that it relies upon)

Answer 4

No, some changes in sequence will have no effect. It depends on the type of change, the extent of the change (point mutation, deletion, etc).