proteins leaking out of blood vessels into interstitial fluid causing edema?

Question

proteins leaking out of blood vessels into interstital fluid, why does this lead to edema

Answer 1

Proteins are water-soluble, meaning that they will attact water to that area and edema will form. That's why your ankle swells when you twist it, damaged cells release proteins and cause fluid to accumulate.

Answer 2

If the membrane of the blood vessel and the interstitial tissue cells are permeable to proteins and these proteins actually leave the blood vessel and diffuse into interstitial fluid, then along with proteins water also would diffuse into the cells making them enlarged. And, there is only so much of capacity for the lymphatic system to take all this extra fluid. When lymphatic system does not clear it up, it eventually results in edema.

Answer 3

protines in the blood keep oncotic pressure. When there is not enough protein in the blood water seeps out of the vessle into the interstitial fluid leading to edema.