Significance of of Bohr effect?

Answer 1

The Bohr effect refers to the fact that an increase in blood carbon dioxide level, a decrease in pH or increased temperature causes hemoglobin to bind to oxygen with less affinity. Obviously this has biological implications.

Answer 2

The Bohr effect was first discovered by a guy named Bohr! He discovered that there were other factors that affected the loading/unloading of oxygen by hemoglobin in the RBC's. One of the factors that he discovered was pH. He found that if the pH was lower than normal (normal physiological pH is 7.4), then hemoglobin does not bind oxygen as well.