what does"dissociation constant" increase or decrease signify ?

Question

in chemical reactions between an enzyme and a ligand ,what does it indicate -in terms of affinity -that a substance has a high dissociation constant while another has a lower one ? plz help me in this so as to be able to interpret data in my chemistry report.

Answer 1

A high dissociation constant implies that the ratio products:reactants is large. Now, if you have separate enzyme and ligands on the left, and a product on the right of an equation, a high dissiciation constant, despite its name (equilibrium constant would be better) would infer great stability of the product - a high affinity.

The term dissociation constant is best left to acids, which do dissociate.