Yes it does have an effect on your hair. See what I found for U.
Development. 2004 Apr ;131:1825-33 15084466
BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice.
[My paper] Munehiro Yuhki , Masahisa Yamada , Masako Kawano , Takuji Iwasato , Shigeyoshi Itohara , Hisahiro Yoshida , Masaharu Ogawa , Yuji Mishina
Interactions between ectodermal and mesenchymal extracellular signaling pathways regulate hair follicle (HF) morphogenesis and hair cycling. Bone morphogenetic proteins (BMPs) are known to be important in hair follicle development by affecting the local cell fate modulation. To study the role of BMP signaling in the HF, we disrupted Bmpr1a, which encodes the BMP receptor type IA (BMPR1A) in an HF cell-specific manner, using the Cre/loxP system. We found that the differentiation of inner root sheath, but not outer root sheath, was severely impaired in mutant mice. The number of HFs was reduced in the dermis and subcutaneous tissue, and cycling epithelial cells were reduced in mutant mice HFs. Our results strongly suggest that BMPR1A signaling is essential for inner root sheath differentiation and is indispensable for HF renewal in adult skin.
Mesh-terms: Animals; Cell Differentiation, physiology; Cytoskeletal Proteins, biosynthesis; Cytoskeletal Proteins, genetics; Hair Follicle, abnormalities; Hair Follicle, pathology; Hair Follicle, physiology; Integrases, genetics; Integrases, metabolism; Mice; Mice, Knockout; Protein-Serine-Threonine Kinases, genetics; Protein-Serine-Threonine Kinases, physiology; Receptors, Growth Factor, genetics; Receptors, Growth Factor, physiology; Signal Transduction, physiology; Support, Non-U.S. Gov't; Trans-Activators, biosynthesis; Trans-Activators, genetics; Viral Proteins, genetics; Viral Proteins, metabolism;
Development. 2004 Apr ;131:1825-33 15028661
BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice.
[My paper] Munehiro Yuhki , Masahisa Yamada , Masako Kawano , Takuji Iwasato , Shigeyoshi Itohara , Hisahiro Yoshida , Masaharu Ogawa , Yuji Mishina
Interactions between ectodermal and mesenchymal extracellular signaling pathways regulate hair follicle (HF) morphogenesis and hair cycling. Bone morphogenetic proteins (BMPs) are known to be important in hair follicle development by affecting the local cell fate modulation. To study the role of BMP signaling in the HF, we disrupted Bmpr1a, which encodes the BMP receptor type IA (BMPR1A) in an HF cell-specific manner, using the Cre/loxP system. We found that the differentiation of inner root sheath, but not outer root sheath, was severely impaired in mutant mice. The number of HFs was reduced in the dermis and subcutaneous tissue, and cycling epithelial cells were reduced in mutant mice HFs. Our results strongly suggest that BMPR1A signaling is essential for inner root sheath differentiation and is indispensable for HF renewal in adult skin
Hope this helps U
2007-01-28 04:48:03
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answer #1
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answered by Blues Man 7
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