what will be the solvent system for the separation of ethylacetate soluble isomeric compounds via tlc?

Answer 1

Err that’s an easy one – Ethylacetate. Any solvent that can even partially dissolve a substance can be used as the mobile phase for chromatography.

Now your question really might be how do I slow down (increase the retention factor) in an ethylacetate system to improve separation? Ethyl acetate is very polar, so you might mix it with a small proportion of a less polar, miscible solvent. This will broaden your bands, but also retard the more polar analytes. Giving you some better separation.

The trick is in selecting the correct diluent solvent and then optimizing the proportions. Much of that is seat of the pants flying. Though there are mathematical models for optimizing the proportions. Best of luck.