while taking lupron and you become pregnant what will this do to the unborn baby?

Question

my daughter in law has endormetriosis and was started on the lupron injections, she has since found out that she is pregnant and has been told this CAN cause damage to the fetus. She is 7 weeks so that would mean that she was about 1-2 weeks when she got the injection. Please help us find out about this

Answer 1

Lupron is a category X drug and thereby contraindicated in pregnancy [use of Lupron during fertility workups are done in an off-label, alternate dose regimen, vs. the injection dosing schedule done for Endometriosis]. However, there is no immediate need for alarm. Here are some facts...

*All* pregnancies are at a 3-5% risk of birth defects or mental retardation.

In terms of Lupron exposure, there may be a *slight* increase in risks to the fetus when a woman is on Lupron at conception. However...this does *not* mean that the baby will be born with a problem, it simply means that Lupron research has revealed that a woman's pregnancy may be at an increased risk for miscarriage or possible defect. The concerns regarding this increased risk are based on the small number of studies of women who were exposed to Lupron during pregnancy, as well as the rat and rabbit models with the drug.

The studies showed that of the 125 women studied [who were exposed to Lupron at the time of pregnancy], 35 miscarried (28%), 1 terminated for Trisomy 18, 3 were ectopic pregnancies (2.4%), and 2 of the 125 total infants had congenital anomalies which included bilateral inguinal hernia and atretic kidney.

In studies of the children born, 1 had a cleft palate, 1 had a seizure disorder, and 3 had ADHD. Again, however, this is a very small study group and is not enough to confirm any forgone conclusions about in utero exposure to any GnRHs.

It is recommend in the clinical research data that Level II ultrasound is performed at 18-20 weeks to confirm the healthy progress of the developing fetus. Maternal Serum Marker Screening may also be considered.

It is imperative that your DIL does not feel any guilt or anxiety over this and that she is afforded a strong support system. Chances are in her favor that everything will be fine. Good luck to you all.

Answer 2

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It's far from impossible - make sure you use a barrier method of birth control during Lupron therapy, as all GnRH drugs are category X (meaning they hold high risks of causing permanent damage to the fetus). Your doctor probably prescribed the BCPs not for contraception, but as addback therapy. Addback is very important to take with Lupron in order to minimize some of the more common side effects, including bone density loss. You should talk to him about his reason and make sure you don't need the pills. If this is your second time on Lupron (meaning you've already undergone a 6 mon. course of the 3.75 mg dosage or a 3 mon. course of 11.25 mg), then you *must* take the addback. The FDA has only approved re-treatment with Lupron provided addback is given. Any other administration is considered off-label and thereby not the accepted standard of care. PS: regarding the above comment re: tubal ligations...evidence-based data shows that an average of 1 out of 100 women become pregnant each year after tubal ligations (having their "tubes tied"). About 1 out of 3 of those subsequent pregnancies are ectopic, which can be potentially life-threatening and require emergency surgery to treat. Tubal ligations are not 100% effective. While the risks of pregnancy are low, if you're that one woman who gets pregnant, possibly with an ectopic, statistics don't matter. But it should be known that even "sterilization" is not 100% effective against pregnancy (unless the surgery also involves removing the uterus).

Answer 3

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RE:
while taking lupron and you become pregnant what will this do to the unborn baby?
my daughter in law has endormetriosis and was started on the lupron injections, she has since found out that she is pregnant and has been told this CAN cause damage to the fetus. She is 7 weeks so that would mean that she was about 1-2 weeks when she got the injection. Please help us find out...

Answer 4

Lupron And Pregnancy

Answer 5

It is important to remember that Lupron is not a contraceptive and it is possible for pregnancy to occur during therapy. Even if you are not having periods, ovulation could occur. so use extra protection!!!! (unless you want to get pregnant then don't)

Answer 6

I was taking Lupron injections during my fertility treatments when trying to get pregnant. Assuming that she's stopped taking it, she should be fine, but I suggest that she ask her doctor to make sure.

Good luck and congrats!

Answer 7

usually nothing...most of the vital organs dont even start to develop yet at one to two weeks...