where Z DNA is found?

Answer 1

Structure:
Z DNA is a variant of B DNA, with slightly different configuration. Z DNA is left handed spiral, has 12 base pairs per turn, and has a diameter of 18 Angstrom.
Fuction:
Z-DNA does not participate in the formation of nucleosomes. Hence it leaves a nucleosome-free region near the transcription start site. This allows transcription factors to be recruited, so that transcription can continue. Most human genes have been found to have Z-DNA-forming sequences near the transcription start site.

For a brief history of Z DNA see wikipedia and for detailed structure see the answer before this one.

Answer 2

Z Form Dna

Answer 3

Z-DNA is an alternative left-handed conformation of the DNA double helix. It was first visualized 20 years ago in this laboratory in an X-ray diffraction analysis. The immediate question asked at the time was: Does it have a biological function? An important advance was made by publication of the crystal structure of Z-DNA bound to a protein domain of an editing enzyme. The crystal structure reveals a detailed fitting of the protein to the DNA, held together by a system of 11 hydrogen bonds and 5 distinct van der Waals interactions. The protein binds to 5 successive phosphate residues on one strand of the Z-DNA double helix and also has a van der Waals contact which can only occur if the base is in the syn conformation which is a hallmark of Z-DNA. This protein domain is one of a family of proteins in which the important residues involved in Z-DNA interaction are strongly conserved.

Conversion of B-DNA to Z-DNA requires an input of energy. That input is provided by movement of RNA polymerase which generates underwound DNA and stabilizes the Z form. Z-DNA is largely found in transcribing genes, and it is there only transiently as the cessation of transcription results in rapid conversion of Z-DNA to right-handed B-DNA through the action of topoisomerases.

The editing enzyme is double-stranded RNA adenosine deaminase. It deaminates adenine to produce inosine which codes as if it were guanine. Thus, it changes amino acids in proteins. Many of these occur in the central nervous system, such as in the glutamate or serotonin receptors. The editing enzyme binds to a hairpin or foldback RNA structure, which forms a double-stranded segment. The editing enzyme consists of three functional domains, one which carries out deamination, one which binds double-stranded RNA and a third which binds left-handed Z-DNA. Double-stranded RNA is often formed by an intronic sequence pairing with an exonic sequence, and an adenine in the exon is then deaminated. This must happen before the removal of introns by the splicing apparatus. Since Z-DNA is found almost exclusively in transcribing genes, it is believed that the Z-DNA binding domain targets the enzyme to the transcribed gene so that it can carry out its editing activities before the introns are removed. The Z-DNA binding domain has a binding constant near 10 nM, and thus may function as a targeting domain.

Answer 4

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RE:
where Z DNA is found?

Answer 5

i dont htink Z DNA is found in nature. Its mostly created in labs, and used in labs

If i remember my third year biochem correctly.
Z DNA is very tightly wound together

Answer 6

from what i remember, there's no "disadvantage", they're just used by different cell types, or during transcription

Answer 7

we have zDNA in areas that there is so many C-G base pair and it can effect on gene amplification

Answer 8

try the link below