variables affecting toxicokinetics
2007-01-16 02:40:20 · 2 answers · asked by che che 1 in Science & Mathematics ➔ Physics
The process of the uptake of potentially toxic substances by the body, the biotransformation they undergo, the distribution of the substances and their metabolites in the tissues and the elimination of the substances and their metabolites from the body. Both the amounts and concentrations of the substances and their metabolites are studied. The term has essentially the same meaning as pharmacokinetics, but the latter term should be restricted to the study of pharmaceutical substances.
2007-01-16 02:46:54 · answer #1 · answered by elvisjohn 7 · 4⤊ 0⤋
Toxicokinetics is the application of pharmacokinetics to determine the relationship between the systemic exposure of a compound in experimental animals and its toxicity. It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans.
Pharmacokinetics is a branch of pharmacology dedicated to the study of the time course of substances and their relationship with an organism or system. In practice, this discipline is applied mainly to drug substances, though in principle it concerns itself with all manner of compounds residing within an organism or system, such as nutrients, metabolites, endogenous hormones, toxins, etc. So, in basic terms, while pharmacodynamics explores what a drug does to the body, pharmacokinetics explores what the body does to the drug.
2007-01-16 10:44:31 · answer #2 · answered by chkn_fur 5 · 0⤊ 0⤋