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Mitochondrial DNA (mtDNA) replication is independent of the cell cycle. Even in post-mitotic cells in which nuclear DNA replication has ceased, mtDNA keeps replicating. In oocytes that undergo vitellogenesis, prior to yolk synthesis, which occurs at pachytene stage of prophase, there is ribosome biogenesis and mitochondrial biogenesis. The abundance of mitochondria is due to their biogenesis and division. But it is a fact that mitochondria have to replicate their DNA prior to cell division. But it is still not known what mechanisms synchronize of cell proliferation and mtDNA replication. Researches have shown that mtDNA is replicated during a specific phase of the cell cycle (the pre-S phase) and that this process is regulated by mitogenic growth factors. Mitochondria are target of intracellular signaling pathways leading to their proliferation.

2006-12-18 21:47:17 · answer #1 · answered by Ishan26 7 · 2 0

Replication is temperature sensitive even when these mutants are arrested in the G1 phase of the cell cycle with alpha factor, a condition where mitochondrial DNA replication continues for the equivalent of several generations at the permissive temperature. Therefore the cessation of replication results from a defect in mitochondrial replication per se, rather than from an indirect consequence of cells being blocked in a phase of the cell cycle where mitochondrial DNA is not normally synthesized. Since the temperature-sensitive mutations are recessive, the products of genes cdc8 and cdc21 must be required for both nuclear and mitochondrial DNA replication. In contrast to cdc8 and cdc21, mitochondrial DNA replication continues for a long time at the nonpermissive temperature in five other cell division cycle mutants in which nuclear DNA synthesis ceases within one cell cycle: cdc4, cdc7, and cdc28, which are defective in the initiation of nuclear DNA synthesis, and cdc14 and cdc23, which are defective in nuclear division. The products of these genes, therefore, are apparently not required for the initiation of mitochondrial DNA replication.

2006-12-18 16:13:13 · answer #2 · answered by Scotty 3 · 1 1

Mitochondria Replication

2016-12-08 19:08:24 · answer #3 · answered by ? 4 · 0 0

In the cell cycle there are two process .i.e. Mitosis & Meosis. Meosis is carried out during the formation of gamates & Mitosis is carried out during the duplication of the cells. In these cell cycle mitochondrial dna replicate.

2006-12-19 16:01:52 · answer #4 · answered by krrish 2 · 0 3

The cell cycle is an ordered set of events, culminating in cell growth and division into two daughter cells.
Non-dividing cells not considered to be in the cell cycle. The stages, pictured to the left, are G1-S-G2-M.
The G1 stage stands for "GAP 1".
The S stage stands for "Synthesis". This is the stage when DNA replication occurs.
The G2 stage stands for "GAP 2".
The M stage stands for "mitosis", and is when nuclear (chromosomes separate) and cytoplasmic (cytokinesis) division occur. Mitosis is further divided into 4 phases.
for more info: http://www.cellsalive.com/cell_cycle.htm

2006-12-18 16:22:33 · answer #5 · answered by TO BE CONTINUED.... 2 · 0 3

Cell organells of an eukaryotic cell replicate during the Interphase.
So does Mitochondria and its DNA.

2006-12-20 19:31:25 · answer #6 · answered by Rohan 2 · 0 1

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DNA is replicated or synthesized during: D. S phase. Here, 'S' stands for 'synthetic'.

2016-04-08 08:01:51 · answer #7 · answered by Anonymous · 0 0

simple answer is "Interphase" --- thats where the dna is duplicated

2006-12-18 16:15:39 · answer #8 · answered by jared131716 1 · 0 1

INTERPHASE

2006-12-18 16:27:45 · answer #9 · answered by Anonymous · 0 1

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