Stem cells are primal cells common to all multicellular organisms that retain the ability to renew themselves through cell division and can differentiate into a wide range of specialized cell types. Research in the human stem cell field grew out of findings by Canadian scientists Ernest A. McCulloch and James E. Till in 1957.
The two categories of human stem cells are embryonic stem cells, derived from blastocysts, and adult stem cells, derived from umbilical cord blood or bone marrow.[1] In a blastocyst of a developing embryo, stem cells differentiate into all of the specialised embryonic tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing specialized cells. As stem cells can be readily grown and transformed into specialized tissues such as muscles or nerves through cell culture, their use in medical therapies has been proposed.
Embryonic stem cell lines (ES cell lines) are cultures of cells derived from the epiblast tissue of the inner cell mass (ICM) of a blastocyst. A blastocyst is an early stage embryo - approximately 4 to 5 days old in humans and consisting of 50-150 cells. ES cells are pluripotent, and give rise during development to all derivatives of the three primary germ layers: ectoderm, endoderm and mesoderm. In other words, they can develop into each of the more than 200 cell types of the adult body when given sufficient and necessary stimulation for a specific cell type. They do not contribute to the extra-embryonic membranes or the placenta.
When given no stimuli for differentiation, ES cells will continue to divide in vitro and each daughter cell will remain pluripotent. The pluripotency of ES cells has been rigorously demonstrated in vitro and in vivo, thus they can be indeed classified as stem cells.
Because of their unique combined abilities of unlimited expansion and pluripotency, embryonic stem cells are a potential source for regenerative medicine and tissue replacement after injury or disease. To date, no approved medical treatments have been derived from embryonic stem cell research. This is not surprising considering that many nations currently have a moratorium on either ES cell research or the production of new ES cell lines.
Adult stem cells are undifferentiated cells found throughout the body that divide to replenish dying cells and regenerate damaged tissues. Also known as somatic (from Greek Σωματικóς, of the body) stem cells, they can be found in children, as well as adults.
A great deal of adult stem cell research has focused on clarifying their capacity to divide or self-renew indefinitely and their differentiation potential. Many adult stem cells may be better classified as progenitor cells, due to their limited capacity for cellular differentiation.
Nevertheless, specific multipotent or even unipotent adult progenitors may have potential utility in regenerative medicine. The use of adult stem cells in research and therapy is not as controversial as embryonic stem cells, because the production of adult stem cells does not require the destruction of an embryo. In contrast with the embryonic stem cell research, more US government funding has been provided for adult stem cell research. Adult stem cells can be isolated from a tissue sample obtained from an adult. They have mainly been studied in humans and model organisms such as mice and rats.
2006-12-06 02:32:57
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answer #1
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answered by DOOM 2
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Stem cells are undifferentiated cells that have the ability to become any other cell type in the body (nerve, muscle, skin, etc.)
The embryo essentially starts out as a stem cell and as it develops the cells become whatever it is they need to be.
2006-12-06 02:33:13
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answer #2
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answered by Ron 3
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Stem cells—Cells with the ability to divide for indefinite periods in culture and to give rise to specialized cells
2006-12-06 02:24:04
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answer #3
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answered by LEEANE G 3
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they are specialized cells that can develop into any type of cell...like a kidney cell or a heart cell etc.
2006-12-06 02:29:16
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answer #5
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answered by eva diane 4
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