Explain: the Role of Bax and Bak in mitochondrial morphogenesis?

Question

Explain Abstract:

Bcl-2 family proteins are potent regulators of programmed cell death. Although their intracellular localization to mitochondria and the endoplasmic reticulum has focused research on these organelles, how they function remains unknown. Two members of the Bcl-2 family, Bax and Bak, change intracellular location early in the promotion of apoptosis to concentrate in focal clusters at sites of mitochondrial division. Here we report that in healthy cells Bax or Bak is required for normal fusion of mitochondria into elongated tubules. Bax seems to induce mitochondrial fusion by activating assembly of the large GTPase Mfn2 and changing its ubmitochondrial distribution and membrane mobility—properties that correlate with different GTP-bound states of Mfn2. Our results show that Bax and Bak regulate mitochondrial dynamics in healthy cells and indicate that Bcl-2 family members may also regulate apoptosis through organelle morphogenesis machineries.

Answer 1

Bax and Bak are VERY important proteins involved in the intrinsic pathway of apoptosis (Whenever you see proteins involved in regulating apoptosis, cell division, or the cell cycle, THINK CANCER). Now in normal cell development:

"Here we report that in healthy cells Bax or Bak is required for normal fusion of mitochondria into elongated tubules. Bax seems to induce mitochondrial fusion by activating assembly of the large GTPase Mfn2 and changing its ubmitochondrial distribution and membrane mobility—properties that correlate with different GTP-bound states of Mfn2. Our results show that Bax and Bak regulate mitochondrial dynamics in healthy cells."

I think that's pretty clear.

Answer 2

How does Mitochondrial DNA clarify the variety of creationism? i'll respond to this for you. something so unique and precise on what it really is meant to do and also you've faith it happend randomly? each and every thing has a author no matter if you wish it or no longer. God might want to be very smart previous human probability to create something so marvelous as Mitochondrial DNA. I ask you in case you've been in a room through your self might want to you're making Mitochondrial DNA?

Answer 3

There are better websites where you can go to get your homework done.

Answer 4

You just did.