How do I breed drosophila melonogaster (fruit flies)?

Answer 1

Observing the Development
of Drosophila in Apple Juice Agar
--> http://www.accessexcellence.org/AE/AEPC/WWC/1994/observing.html

Answer 2

If you're trying to do a specific cross between two different varieties of flies, it is very important that you start with virgin female flies. You have to isolate these flies within a few hours after they emerge from their pupae. Just put those virgin females into a vial with food and add some males of the other variety, and they'll just do their thing and mate.