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2006-11-12 11:36:08 · 3 answers · asked by Anonymous in Science & Mathematics Chemistry

3 answers

COOH is a carboxylic acid group. It's more correct to write it as:
-COOH, where the line indicates the unused electron that would form a bond.

2006-11-12 11:57:52 · answer #1 · answered by pack_rat2 3 · 0 0

The only COOH I have come to know is the fibronectin one.
29 kDa protease fragment of fibronectin containing the COOH-terminal heparin-binding domain (HepII)(DeltaC92)
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Fibrinogen is a major plasma protein (350 kDa) that induces proliferative signals by serving as a scaffold to support the binding of growth factors and to promote the cellular responses of adhesion, proliferation, and migration during wound healing, angiogenesis, and tumor growth. Fibrin(ogen) degradation products generated during fibrinolysis are implicated in tissue injury. The fibrinogen gamma chain has a COOH-terminal globular domain (gammaC, residues 151-411 of the gamma chain, 30 kDa) to which several integrin cell adhesion receptors (e.g., platelet alpha(IIb)beta(3), endothelial alpha(v)beta(3), and leukocyte alpha(M)beta(2)) bind. Integrins play a critical role in signal transduction from fibrin(ogen). We found that gammaC and its truncation mutant (designated gammaC399tr), with a deletion of the COOH-terminal 12 residues, induced apoptosis of endothelial cells and blocked tube formation of endothelial cells. DLD-1 human colon cancer cells that secrete gammaC or gammaC399tr grew at similar levels in vitro but grew much slower in vivo than mock-transfected cells. The recombinant purified gammaC399tr fragment markedly suppressed tumor growth, development of intratumoral vasculature, and tumor metastasis in vivo in the highly metastatic Met-1 breast cancer model. The determinant responsible for binding to endothelial cells is cryptic in native fibrinogen but is exposed in gammaC and gammaC399tr. These results suggest that fibrinogen has a novel cryptic determinant, which can exert apoptosis-inducing activity on endothelial cells when exposed, and polypeptides containing this determinant have therapeutic potential. (Cancer Res 2006; 66(19): 9691-7)
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Maybe this one?
---Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L7, Canada. hoaretr@mcmaster.ca

A kinetic model accounting for the copolymerization of up to four comonomers is applied to predict both chain and radial functional group distributions in carboxylic-acid-functionalized poly(N-isopropylacrylamide) (NIPAM)-based microgels. The model can accurately predict the experimentally observed radial distributions of functional monomers in microgels prepared using a variety of different carboxylic-acid-functionalized monomers with significantly different hydrophobicities, copolymerization kinetics, and reactivities, without requiring the use of adjustable parameters. Multimodal distributions can both be predicted and experimentally generated by copolymerizing two -COOH-containing monomers with widely different reactivities. Chain distributions and monomer block formation can also be probed using the kinetic model, allowing for qualitative predictions of the potentiometric titration behavior of the microgels. The kinetic model reported herein therefore provides the first available analytical method for semiquantitatively predicting and controlling functional group distributions in bulk-polymerized microgel systems.

2006-11-12 11:56:56 · answer #2 · answered by QuiteNewHere 7 · 1 0

No. break it down to its components.

2006-11-12 11:42:45 · answer #3 · answered by Anonymous · 0 0

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