What are the methods of preparation and uses of Lithium diisopropyl amide?

Question

LDA

Answer 1

LDA is formed by treating a cooled (-78 °C) THF solution of dried and distilled diisopropylamine (CAS 108-18-9) with 100 mol-% n-butyllithium (typically a hexane solution) and allowing the reaction temperature to reach either 0 °C or room temperature.

Lithium diisopropylamide is a strong base, widely used in organic chemistry for the generation of carbanions.