Can anyone explain the MAP Kinase pathway to me?

Question

Please specify the ligand, receptor, secondary messengers and the outcome within the cell. Thanks.

Answer 1

http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=dbio.TOC&depth=2

Above is a link to an online book for developmental biology.
Below is the info at wikipedia.

In cell biology, mitogen-activated protein (MAP) kinases (EC 2.7.11.24) are serine/threonine-specific protein kinase that respond to extracellular stimuli (mitogens) and regulate various cellular activities, such as gene expression, mitosis, differentiation, and cell survival/apoptosis [1]. Extracellular stimuli lead to activation of a MAP kinase via a signaling cascade ("MAPK cascade") composed of MAP kinase, MAP kinase kinase (MKK or MAP2K), and MAP kinase kinase kinase (MKKK or MAP3K, EC 2.7.11.25)[1]. A MAP3K that is activated by extracellular stimuli phosphorylates a MAP2K on its serine and threonine residues, and then this MAP2K activates a MAP kinase through phosphorylation on its serine and tyrosine residues. This MAP kinase signaling cascade has been evolutionarily well-conserved from yeast to mammals.

To date, four distinct groups of MAPKs have been characterized in mammals:

extracellular signal-regulated kinases (ERKs)
c-Jun N-terminal kinases (JNKs)
p38 isoforms
ERK5
MAPK is involved in the action of most nonnuclear oncogenes. It is responsible for cell response to growth factors such as BDFN or nerve growth factor. The ERKs (also known as classical MAP kinases) signaling pathway is preferentially activated in response to growth factors and phorbol ester (a tumor promoter), and regulates cell proliferation and cell differentiation. The JNKs (also known as stress-activated protein kinases; SAPKs) and p38 signaling pathways are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation and apoptosis. And ERK5, which has been found recently, is activated both by growth factors and by stress stimuli, and it participates in cell proliferation.

Answer 2

MAP Kinase stands for mitogen activated protein kinase. when you consider which you asked for a uncomplicated clarification, that's between the various cellular proteins that function in sign transduction. enable's say that a protein in contact in triggering cellular growth binds to its receptor on the exterior of the cellular. MAPK may well be between the kinases activated in a protracted chain reaction of proteins in the direction of making modifications in the cellular. All kinases incredibly recommend that their roll is phosphorylation, so it phosphorylates yet another protein, which then phosphorylates yet another protein, till commonly it gets to a transcription ingredient or nuclear receptor...which then motives modifications in gene expression.