The serendipitous discovery of penicillin is usually attributed to Scottish scientist Alexander Fleming in 1928, though others had earlier noted the antibacterial effects of Penicillium. Fleming, at his laboratory in St. Mary's Hospital (Now one of Imperial College teaching hospitals) in London, noticed a halo of inhibition of bacterial growth around a contaminant blue-green mould on a Staphylococcus plate culture. Fleming concluded that the mould was releasing a substance that was inhibiting bacterial growth and lysing the bacteria. He grew a pure culture of the mould and discovered that it was a Penicillium mould, now known to be Penicillium chrysogenum.
In 1939, Australian scientist Howard Walter Florey and a team of researchers (Ernst Boris Chain, A. D. Gardner, Norman Heatley, M. Jennings, J. Orr-Ewing and G. Sanders) at the Sir William Dunn School of Pathology, University of Oxford made significant progress in showing the in vivo bactericidal action of penicillin. Their attempts to treat humans failed due to insufficient volumes of penicillin, but they proved its harmlessness and effect in mice.
2006-10-17 17:55:54
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answer #1
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answered by Zarama 5
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Alexander Fleming, 1881 - 1955, from Scotland.
Quoting http://www.pbs.org/wgbh/aso/databank/bioindex.html:
In 1928 he was straightening up a pile of Petri dishes where he had been growing bacteria, but which had been piled in the sink. He opened each one and examined it before tossing it into the cleaning solution. One made him stop and say, "That's funny." Some mold was growing on one of the dishes -- not too unusual -- but all around the mold, the staph bacteria had been killed -- very unusual. He took a sample of the mold. He found that it was from the penicillium family, later specified as penicillium notatum. Fleming presented his findings in 1929, but raised little interest. He published a report on penicillin and its potential uses in the British Journal of Experimental Pathology. Fleming worked with the mold for some time, but refining and growing it was a difficult process better suited to chemists. The work was taken over by a team of chemists and mold specialists, but was cut short when several of them died or relocated. It took World War II to revitalize interest in penicillin, and Howard Florey and Ernst Chain picked up the work.
In recognition for his contribution, Alexander Fleming was knighted in 1944. With Chain and Florey he was awarded the Nobel Prize in 1945.
2006-10-18 02:11:15
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answer #2
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answered by emerald_trout 4
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An Austrian named Alexander Fleming
2006-10-18 01:05:10
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answer #3
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answered by franklino 4
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The serendipitous discovery of penicillin is usually attributed to Scottish scientist Alexander Fleming in 1928, though others had earlier noted the antibacterial effects of Penicillium. Fleming, at his laboratory in St. Mary's Hospital in London, noticed a halo of inhibition of bacterial growth around a contaminant blue-green mould on a Staphylococcus plate culture. Fleming concluded that the mould was releasing a substance that was inhibiting bacterial growth and lysing the bacteria. He grew a pure culture of the mould and discovered that it was a Penicillium mould, now known to be Penicillium chrysogenum. Fleming coined the term "penicillin" to describe the filtrate of a broth culture of the Penicillium mould. Even in these early stages, penicillin was found to be most effective against Gram-positive bacteria, and ineffective against Gram-negative organisms and fungi. He expressed initial optimism that penicillin would be a useful disinfectant, being highly potent with minimal toxicity compared to antiseptics of the day, but particularly noted its laboratory value in the isolation of "Bacillus influenzae" (now Haemophilus influenzae). After further experiments, Fleming was convinced that penicillin could not last long enough in the human body to kill pathogenic bacteria and stopped studying penicillin after 1931, but restarted some clinical trials in 1934 and continued to try to get someone to purify it until 1940.
In 1939, Australian scientist Howard Walter Florey and a team of researchers (Ernst Boris Chain, A. D. Gardner, Norman Heatley, M. Jennings, J. Orr-Ewing and G. Sanders) at the Sir William Dunn School of Pathology, University of Oxford made significant progress in showing the in vivo bactericidal action of penicillin. Their attempts to treat humans failed due to insufficient volumes of penicillin, but they proved its harmlessness and effect in mice. Some of the pioneering trials of penicillin took place at the Radcliffe Infirmary in Oxford. On 1942-03-14 John Bumstead and Orvan Hess became the first in the world to successfully treat a patient using penicillin.
2006-10-18 01:03:31
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answer #4
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answered by Anonymous
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I'll do some research...OK...Dr. Alexander Fleming was Scottish. He left for a vacation and upon his return noticed he left some bacteria samples out. He took the greenish mold substance, grew more, and found that where the mold grew, there was no bacteria...the story then began for the production of penicillin...kewl huh?!
2006-10-18 01:12:54
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answer #5
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answered by Anonymous
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Believe he was an Austrian,
2006-10-18 00:58:37
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answer #6
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answered by Anonymous
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