2006-10-13 01:35:58 · 3 answers · asked by Lady E 1 in Science & Mathematics ➔ Chemistry
Conjugated linoleic acids (CLA) are a group of positional and geometric conjugated dienoic isomers of linoleic acid. The objective of this study was to determine the effects of the cis-9,trans-11 and trans-10,cis-12 isomers of conjugated linoleic acid on lipid composition and gene expression during the differentiation of mouse 3T3-L1 preadipocytes. Treatment of differentiating 3T3-L1 preadipocytes with trans-10,cis-12 conjugated linoleic acid (CLA) resulted in a dose-dependent decrease in the expression of the stearoyl-CoA desaturase 1 gene (SCD1). The expression of other adipocyte genes such as adipose P2 (aP2), fatty acid synthase (FAS), SCD2 and the key adipogenic transcription factors, peroxisome proliferator-activated receptor γ2 (PPARy2) and CCAAT enhancer binding protein a (C/EBPa), remained elevated. Cells treated with trans-10,cis-12 CLA exhibited smaller lipid droplets, with reduced levels of the major monounsaturated fatty acids, palmitoleate and oleate. By contrast, the cis-9,trans-1 1 isomer did not alter adipocyte gene expression. Repression of the stearoyl-CoA desaturase gene expression in adipocytes by the trans-10,cis-12 isomer may contribute to the mechanisms by which CLA reduces body fat in mice
2006-10-13 01:41:17 · answer #1 · answered by ☺♥? 6 · 0⤊ 0⤋
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2014-11-13 23:00:27 · answer #2 · answered by ? 3 · 0⤊ 0⤋
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2006-10-13 08:43:41 · answer #3 · answered by dreamer 3 · 0⤊ 0⤋