How pyridine will affect on the sexual behavior of man/women?

Question

since i heard pyridine will decrease male sexual potency.. i am not sure how this will act.. and what are the consequences.. i neeed to know more about it... will any one help me?

Answer 1

Vaccinia virus dUTPase, an enzyme encoded by the nonessential, early phase gene ORF F2L, is a critical component of the de novo pyridine biosynthetic pathway whose function is also important to the maintenance of DNA replication fidelity. DUTPase hydrolyzes dUTP to dUMP and pyrophosphate, a reaction which simultaneously furnishes thymidylate synthetase with its substrate, dUMP, and reduces the intracellular dUTP.dTTP ratio, thereby preventing the misincorporation of dUTP into nascent DNA molecules. Mutagenic U-DNA activates an interactive excision-repair process catalyzed by uracil DNA-glycosylase, which ultimately leads to chromosome fragmentation and cell death. An understanding of how vaccinia virus dUTPase production and activity are regulated in vivo will provide insight into the processes of DNA replication and viral pathogenesis, and will aid in anti-viral drug design. Therefore, profiles of vaccinia virus dUTPase expression, stability, activity, and phosphorylation spanning the eight-hour viral replication cycle in BSC40 cells were generated. Although dUTPase is translated between two and five hours post-infection (hpi), the enzyme is long-lived and does not undergo appreciable turnover through 10 HPI. Once translated, the enzyme is phosphorylated immediately, and shows basal levels of activity. A dramatic increase in dUTPase phosphorylation levels is seen between five and six hpi, which coincides with the steady rise in catalytic activity seen late in infection must be the result of a positive post-translational regulatory mechanism. It was proposed that phosphorylation events allosterically active dUTPase, due to the strong correlation between dUTPase activity and phosphorylation levels throughout infection. In order to identify the phosphorylated residues, phosphoamino acid analysis was performed on immunopurified dUTPase using a 2D-TLC system. Preliminary experiments suggest that vaccinia virus dUTPase is phosphorylated on tyrosine and threonine residues in vivo.

Answer 2

it doesn't.........