In which cellular compartment does the Hexokinase reaction in glycolysis process take place??

Answer 1

Hexokinase phosphorylates glucose in the first step of glycolysis. Glycolysis occurs in the cytoplasm. It is only after glycolysis that pyruvate enters the mitochondria to take part in the krebs cycle.

(Some of the hexokinase isoforms are attached to the mitochondrial membrane, but the answer to your question is the cytoplasm.)

Try looking up cellular respiration, hexokinase and glycolysis if you need more information.

Answer 2

The initial breakdown of the glucose molecule does take place in the cytoplasm, but most of the rest of glycolysis takes place in the matrix of the mitochondria. I don't off hand remember if hexokinase is a part of the process or where in the chain reaction it would be.

Answer 3

This appears to be an exam question. As I am neither a scientist nor a biologist, I cannot even begin to understand the question let alone answer it.
I would however suggest you just type in 'Hexokinase Reaction' into a search engine and see what results you get.
The internet is a wonderful thing!!!

Answer 4

Glycolysis is one of the most universal metabolic processes known, and occurs (with variations) in many types of cells in nearly all types of organisms. Glycolysis alone produces less energy per glucose molecule than complete aerobic oxidation, and so flux through the pathway is greater in anaerobic conditions (i.e., in the absence of oxygen).
Hexokinase is inhibited by glucose-6-phosphate (G6P), the product it forms through the ATP driven phosphorylation. This is necessary to prevent an accumulation of G6P in the cell when flux through the glycolytic pathway is low. Glucose will enter the cell but since the hexokinase is not active it can readily diffuse back to the blood through the glucose transporter in the plasma membrane. If hexokinase remained active during low glycolytic flux the G6P would accumulate and the extra solute would cause the cells to enlarge due to osmosis.

In liver cells, the extra G6P is stored as glycogen. In these cells hexokinase is not expressed, instead glucokinase catalyses the phosphorylation of glucose to G6P. This enzyme is not inhibited by high levels of G6P and glucose can still be converted to G6P and then be stored as glycogen. This is important when blood glucose levels are high. During hypoglycemia the glycogen can be converted back to G6P and then converted to glucose by a liver specific enzyme glucose 6-phosphatase. This reverse reaction is an important role of liver cells to maintain blood sugars levels during fasting. This is critical for neuron function since they can only use glucose as an energy source.
VR

Answer 5

In Cytoplasm. Infact, all the reactions in the pathway take place in cytoplasm.

Answer 6

The one in my brain that doesnt know.