Lipids are a class of hydrocarbon-containing organic compounds essential for the structure and function of living cells. Lipids are categorized by the fact that they are soluble in nonpolar solvents (such as ether and chloroform) and are relatively insoluble in water. Lipid molecules have these properties because they consist of mainly carbon and hydrogen, with few oxygen-containing functional groups. Some lipids are used for energy storage, others serve as structural components of cellular membranes, and some are important hormones. Although the term lipid is often used as a synonym for fat, the latter is in fact a subgroup of lipids called triglycerides.
Types of lipids
Structure of a Lipid
Many lipids consist of a polar head group (P) and a nonpolar tail (U for unpolar). The lipid shown is a phospholipid (two tails). The image on the left is a zoomed version of the more schematic image on the right, which will be used from now on to represent lipids with one. two, or three chains.Along with proteins, nucleic acids and carbohydrates, lipids are one of the major classes of biologically important molecules or biomolecules. However, unlike these other groups of molecules, lipids comprise a broader and more diverse range of structures. The term lipid really is a catch-all phrase for a wide variety of hydrocarbon-based molecules of biological origin that are predominantly nonpolar or hydrophobic ("water-fearing"), meaning that they do not interact well with polar solvents like water, and are instead soluble in less polar organic solvents. Most lipids also have some polar or hydrophilic ("water-loving") character. This makes them amphipathic or amphiphilic molecules (having both hydrophobic and hydrophilic portions). In the case of cholesterol, the polar group is a mere -OH (hydroxyl or alcohol). In the case of phospholipids, the polar groups are considerably larger and more polar. Lipids encompass a huge range of structures. They can be aliphatic or aromatic. They can be acyclic or cyclic, straight or branched, saturated or unsaturated. Lipids can be flexible or rigid. This diversity makes it impossible to define lipids on the basis of a single core structural feature or biosynthetic origin, as can be done with the other major groups of biomolecules. The basic classes of lipids are:
Fatty acids
Saturated
Unsaturated
Glycerides or glycerolipids
Monoglycerides
Diglycerides
Triglycerides (neutral fats)
Phosphoglycerides or glycerophospholipids
Nonglycerides
Sphingolipids
Sterol lipids (includes cholesterol and steroid hormones)
Prenol lipids (includes terpenoids)
Waxes
Polyketides
More complex lipid derivatives
Sugar-linked lipids: glycolipids
Protein-linked lipids
Note: There are different ways to classify lipids. A comprehensive new classification system has been proposed recently (J. Lipid Res. 46:839), which instead divides lipids into: (1) fatty acyls, (2) glycerolipids, (3) glycerophospholipids, (4) sphingolipids, (5) sterol lipids, (6) prenol lipids, (7) saccharolipids and (8) polyketides.
Lipid functions
Cell membranel structure
Constitutes a barrier for the cell
Controls membrane fluidity
Controls the flow of material in and out of the cell
Energy storage (for instance, fats stored in adipose tissue)
Lipid hormones like steroids and eicosanoids - mediate communication between cells
Signal transduction - function in the transmission of information in cells
Lipid vitamins - required for metabolism, usually as coenzymes
Structure
Fatty acids and glycerides
Main article: fatty acid
Chemically, fatty acids can be described as long-chain monocarboxylic acids and have a general structure of CH3(CH2)nCOOH. The length of the chain usually ranges from 12 to 24, always with an even number of carbons. When the carbon chain contains no double bonds, it is called saturated. If it contains one or more such bonds, it is unsaturated. The presence of double bonds generally reduces the melting point of fatty acids. Furthermore, unsaturated fatty acids can occur either in cis or trans geometric isomers. In most naturally occurring fatty acids, the double bonds are in the cis configuration.
Glycerides are lipids possessing a glycerol core structure with one or more fatty acyl groups, which are fatty acid-derived chains attached to the glycerol backbone by ester linkages. Glycerides with three acyl groups (triglycerides or neutral fats) are the main storage form of fat in animals and plants.
An important type of glyceride-based molecule found in biological membranes, such as the cell's plasma membrane and the intracellular membranes of organelles, are the phosphoglycerides or glycerophospholipids. These are phospholipids that contain a glycerol core linked to two fatty acid-derived "tails" by ester or, more rarely, ether linkages and to one "head" group by a phosphate ester linkage. The head groups of the phospholipids found in biological membranes are phosphatidylcholine (lecithin), phosphatidylethanolamine, phosphatidylserine and phosphatidylinositol. These phospholipids are subject to a variety of reactions in the cell: for instance, polar head groups or fatty acid tails can be released from specific phospholipids through enzyme-catalyze hydrolysis to generate second messengers involved in signal transduction. In the case of phosphatidylinositol, the head group can be enzymatically modified by the addition of one to three phosphate molecules, and this constitutes another mechanism of cell signaling. While phospholipids are the major component of biological membranes, other non-glyceride lipid components like sphingolipids and sterols (such as cholesterol in animal cell membranes) are also found in biological membranes.
A biological membrane is a form of lipid bilayer, as is a liposome. Formation of lipid bilayers is a spontaneous process when the glycerophospholipids described above are placed in water. In an aqueous milieu, the polar heads of lipids tend to oriente toward the polar, aqueous environment, while the hydrophobic tails tend to minimize their contact with water. The nonpolar tails of lipids (U) tend to cluster together, forming a lipid bilayer (1) or a micelle (2). The polar heads (P) face the aqueous environment. Micelles form when single-tailed amphiphilic lipids are placed in a polar milieu, while lipid bilayers form when two-tailed phospholipids are placed in a polar environment (Fig. 2). Micelles are "monolayer" spheres and can only reach a certain size, whereas bilayers can be considerably larger. They can also form tubules. Bilayers that fold back upon themselves form a hollow sphere, enclosing a separate aqueous compartment, which is the basis of biological membranes.
Micelles and bilayers separate out from the polar milieu by a process known as the "hydrophobic effect." When dissolving a nonpolar substance in a polar environment, the polar molecules (i.e. water in an aqueous solution) become more ordered around the dissolved nonpolar substance, since the polar molecules cannot form hydrogen bonds to the nonpolar molecule. Therefore, in an aqueous environment, the polar water molecules form an ordered "clathrate" cage around the dissolved nonpolar molecule. However, when the nonpolar molecules separate out from the polar liquid, the entropy (state of disorder) of the polar molecules in the liquid increases. This is essentially a form of phase separation, similar to the spontaneous separation of oil and water into two separate phases when one puts them together.
The self-organisation depends on the concentration of the lipid present in solution. Below the critical micelle concentration, the lipids form a single layer on the liquid surface and are dispersed in solution. At the first critical micelle concentration (CMC-I), the lipids organise in spherical micelles, at the second critical micelle concentration (CMC-II) into elongated pipes, and at the lamellar point (LM or CMC-III) into stacked lamellae of pipes. The CMC depends on the chemical composition, mainly on the ratio of the head area and the tail length.
Nutrition and health
Lipids play diverse and important roles in nutrition and health. Many lipids are absolutely essential for life. However, there is also considerable awareness that abnormal levels of certain lipids, particularly cholesterol (in hypercholesterolemia) and, more recently, trans fatty acids, are risk factors for heart disease and other diseases.
2006-10-01 14:45:45
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answer #1
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answered by THE UNKNOWN 5
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It depends on the type of liquid. Water is a polar molecule, while oil is non-polar. Something like ether will dissolve better in oil because it's non-polar, while something like alcohol (ethanol that is) will dissolve in water because it is slighty polar. In fact, it is "completly miscible" which means alcohol and water mix in any proportion. The rule they teach in chemistry is "like dissolves like." So polar molecules dissolve polar molecules and non-polar molecules dissolve non-polar molecules.
Polar simply means that the molecules themselves have a slightly positively charged end and a slightly negatively charged end.
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Lipids are fats, and they are mostly non-polar hydrocarbon chains. They will dissolve in oils. Oils are a kind of lipid.
2006-10-01 14:40:52
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answer #3
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answered by V L 3
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Answer is Yes and No. Depending on what kind of liquid you are looking at and how is the molecular structure is all about. If it is a stable one, will be unlikely to have reaction, but perhaps bonding could be.
Heavy chain of petroleum (Diesel, petrol, bitumen.. etc) are hardly dissolve in oil and water, unless there is a "EMULSION" Process going on.
Well, i will personally say it is all depending.
2006-10-01 14:46:59
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answer #5
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answered by Mr. Logic 3
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