what is cystitis? In liver is their any risk factor?How can we overcome?

Question

My friend raju aged 56,got his medical report,they show a impression that small liver cyst.Can you give detailed answer for this.I am excepting your valuable reply.

Answer 1

Cystitis is an inflammation of the bladder, sometimes involving the tube that drains urine from the bladder, called the urethra.

Bacterial infection causes most bouts of cystitis. Although the urinary tract is normally sterile, germs sometimes may enter the body through the urethra and grow inside the bladder.

This bacterial growth causes the inside walls of the bladder to become inflamed. That inflammation leads to the common symptoms of cystitis.

Elderly people are at increased risk for cystitis primarily because they often cannot empty their bladders completely.

# EnlargedprostateA muscular-like gland at the base of a man's urethra. gland, a common condition as men age. An enlarged prostate can slow the flow of urine, which fosters bacterial growth.

# Inflammation of the prostate gland in men, a condition called prostatitisInflammation of the prostate gland..

# Narrowing of the urethral opening, a common occurrence in people who are older.

# Inability to control the bowels.

# Decreased mobility or total immobility.

# Poor nutrition. Older people often eat and drink less than they should. Poor eating can increase risk of infection. Drinking too little can cause urine to become concentrated and to foster bacterial growth.















How Can I Prevent Further Attacks?

Almost all people who have recurring cystitis have nothing
seriously wrong. People with more than three bouts a year may
need to see a urologist.

Many people who suffer recurring bouts may simply do common things that make them more susceptible. Here are some steps you can take to help prevent cystitis:

* Urinate frequently. This is the single best prevention.

* Drink lots of fluids.

* Women should always wipe front to back.

* Keep the perineal area clean to avoid spreading bacteria from the anal area to the urethra.

* Wear underwear made of cotton only-not silk, nylon, or other fabrics.


Don't use:

* Harsh soaps

* Bubble baths

* Feminine hygiene sprays

* Deodorized tampons

* Douches

* Hot tubs that may not be kept clean

Don't wear:

* Anything tight-fitting for long periods of time. This includes tummy control panties, girdles, stretch pants, or shorts.

* Underwear made with polyester, nylon, or stretch materials.


It's important to urinate when you feel the need, instead of waiting


How Is Cystitis Treated?

Cystitis is almost always treated with medication.

These medications include:

* Oral antibiotics

* Painkillers

* Antispasmodics

Surgery is rarely used to treat cystitis. It can occasionally be useful for treating people with interstitial cystitis.

Surgery also can be useful for correcting an underlying structural blockage or abnormality that is causing recurring cystitis.
Oral Antibiotics

Oral antibiotics are the most common medications used to treat cystitis. They kill the bacteria that are causing the infection.

* Symptoms usually disappear within a few days, and further tests probably will be unnecessary.

* If symptoms continue beyond that time or increase in severity, check with the doctor.

* Some experts say that any woman with persistent symptoms of cystitis should receive antibiotics, even if the urine shows low-to-normal bacteria counts.


How Is Cystitis Treated?

Cystitis is almost always treated with medication.

These medications include:

* Oral antibiotics

* Painkillers

* Antispasmodics

Surgery is rarely used to treat cystitis. It can occasionally be useful for treating people with interstitial cystitis.

Surgery also can be useful for correcting an underlying structural blockage or abnormality that is causing recurring cystitis.
Oral Antibiotics

Oral antibiotics are the most common medications used to treat cystitis. They kill the bacteria that are causing the infection.

* Symptoms usually disappear within a few days, and further tests probably will be unnecessary.

* If symptoms continue beyond that time or increase in severity, check with the doctor.

* Some experts say that any woman with persistent symptoms of cystitis should receive antibiotics, even if the urine shows low-to-normal bacteria counts.

Nice To Know:

Tips on taking antibiotics:

* Take exactly as directed.

* Be sure to finish taking all of the antibiotic prescribed. Not completing the course of treatment can let the bacteria regrow and become resistant to the drug.

* If you are pregnant or suspect you are, make sure your health care provider knows.

* Take the drug at bedtime to help it work the most effectively.

Many experts worry that widespread use of antibiotics causes them eventually to become ineffective. That happens when bacteria that certain antibiotics used to kill quickly become resistant to these medications.

Penicillin and sulfa drugs were once common treatments for cystitis. Today, about a third of bacterial strains causing urinary tract infectionsInfections involving all or part of the kidneys, ureters, bladder and urethra. Often called UTIs. have become resistant to these medications.

Because bacterial resistance is increasing for other antibiotics, as well, your health care professional may change the usual antibiotic treatment regimen.

Antibiotics often used to treat cystitis include:

* Amoxicillin

* Sulfa drugs (sulfonamides)

* Cephalosporins

* Nitrofurantoin

* Doxycycline

* Trimethoprim-sulfamethoxazole

People with serious recurring or chronic cystitis need thorough treatment because of risk for kidney infection.

* Your doctor may recommend long-term antibiotic therapy and request a urine culture.

* Sometimes stronger-than-normal antibiotics may prove useful.

Combinations of drugs also may work.

Answer 2

A liver cyst is not cystitis. cystitis refers to inflamation of a bladder, either urinary bladder or gall bladder, which is local to the liver. Maybe there is inflamation of a cyst in the liver, and that truely can be called cystitis, but I would try to pin down from the doctor exactly what is meant as it leaves too much up in the air. Medical dictionary says cysts in the liver are usually secondary to another disorder. {Always suspect medication/medication history along with other causes]. See the Merck Manual now free online, it is a good resource of trusted medical information for doctors.

Answer 3

What is cystitis?

Cystitis is an infection of the bladder, but the term is often used indiscriminately and covers a range of infections and irritations in the lower urinary system. It causes burning sensations during urination and a frequent need to urinate.

How do you get cystitis?

Infection from intestinal bacteria is by far the most frequent cause of cystitis, especially among women, who have a very short urethra (the tube through which the urine passes from the bladder to the outside). Normally, urine is sterile (there are no micro-organisms such as bacteria present). Between 20 to 40 per cent of women will get cystitis in their lifetime.

However, it is possible to have bacteria in the bladder without having any symptoms. There can be several reasons for the bacteria settling in the bladder. When a person is unable to empty the bladder completely by urinating, it is called urine retention. The small drop which is always left behind may contain bacteria. Conditions that may make it easier for the bacteria to travel through the urethra include those listed below.


Toilet hygiene

Particularly common among females, as they have a shorter urethra than males and it is situated relatively close to their anus (back passage). Women and girls must dry themselves from front to back, towards the anus - not the other way around - to avoid leading bacteria from their intestine into their urethra.


Congenital deformity in the urinary system

In the case of repeated infections of the urinary system, particularly among boys and young men, the individual should be checked for a congenital (present from birth) deformity somewhere in the urinary system which prevents the complete emptying of the bladder.


People with a catheter

Everyone with a catheter (to drain urine) will have bacteria in their bladder, usually without symptoms. During the change of catheter, small lesions (damaged areas) may appear, which may increase the danger of infection (cystitis) and possible blood infection.


Men with an enlarged prostate

An enlarged prostate (male sex gland) prevents the bladder from emptying completely.


Pregnant women

If pregnant women have bacteria in their urine, their urine should be cultured twice, regardless of whether or not they have any symptoms. If the same strains of bacteria occur, they should be treated. Otherwise, there is the risk of kidney infection and pre-term delivery (if near the due date).

Answer 4

Can You Catch Cystitis

Answer 5

Cystitis and Liver cyst are two entirely different issues. Cystitis is inflammation of urinary bladder whereas Liver cyst is a space occupying lesion filled with fluid in liver. The liver cyst can be of bacterial or amebic in nature, depending on the infection. A important variant is Hydatid cyst of Liver. The cyst may not be having any infection either. Depending on the presentation of the patient the physician decides whether the person requires any invasive procedure or not. A simple cyst in liver without any signs of inflammation / infection may not require any treatment even.

Cystitis on the other hand is a disease of urinary bladder and is usually due to recurrent infection of the bladder. Often it is secondary to some outflow obstruction like prostate gland enlargement or urethral stricture.
So the question needs to be modified whether you want to know about urinary bladder cystitis or about Liver cyst. I think you mean to ask about liver cyst

Answer 6

well first let him stop drinking alcohol! 2 of my cousins died in 6 mos after diagnosis! see a doctor and do something early! liver disease are hard to cure! good luck!

Answer 7

If you are a non vegitarion ?.
It is some bacteria.
Bacteria spreads.
Consult your doctor not Mr.Raju.

Answer 8

What is IC / PBS?

Interstitial cystitis (IC) is a condition that results in recurring discomfort or pain in the bladder and the surrounding pelvic region. The symptoms vary from case to case and even in the same individual. People may experience mild discomfort, pressure, tenderness, or intense pain in the bladder and pelvic area. Symptoms may include an urgent need to urinate (urgency), a frequent need to urinate (frequency), or a combination of these symptoms. Pain may change in intensity as the bladder fills with urine or as it empties. Women's symptoms often get worse during menstruation. They may sometimes experience pain with vaginal intercourse.

Because IC varies so much in symptoms and severity, most researchers believe that it is not one, but several diseases. In recent years, scientists have started to use the term painful bladder syndrome (PBS) to describe cases with painful urinary symptoms that may not meet the strictest definition of IC. The term IC / PBS includes all cases of urinary pain that can't be attributed to other causes, such as infection or urinary stones. The term interstitial cystitis, or IC, is used alone when describing cases that meet all of the IC criteria established by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

In IC / PBS, the bladder wall may be irritated and become scarred or stiff. Glomerulations (pinpoint bleeding caused by recurrent irritation) often appear on the bladder wall. Hunner's ulcers are present in 10 percent of patients with IC. Some people with IC / PBS find that their bladders cannot hold much urine, which increases the frequency of urination. Frequency, however, is not always specifically related to bladder size; many people with severe frequency have normal bladder capacity. People with severe cases of IC / PBS may urinate as many as 60 times a day, including frequent nighttime urination (nocturia).

IC / PBS is far more common in women than in men. Of the estimated 1 million Americans with IC, up to 90 percent are women.

What causes IC?

Some of the symptoms of IC / PBS resemble those of bacterial infection, but medical tests reveal no organisms in the urine of patients with IC / PBS. Furthermore, patients with IC / PBS do not respond to antibiotic therapy. Researchers are working to understand the causes of IC / PBS and to find effective treatments.

In recent years, researchers have isolated a substance found almost exclusively in the urine of people with interstitial cystitis. They have named the substance antiproliferative factor, or APF, because it appears to block the normal growth of the cells that line the inside wall of the bladder. Researchers anticipate that learning more about APF will lead to a greater understanding of the causes of IC and to possible treatments.

Researchers are beginning to explore the possibility that heredity may play a part in some forms of IC. In a few cases, IC has affected a mother and a daughter or two sisters, but it does not commonly run.

How is IC / PBS diagnosed?

Because symptoms are similar to those of other disorders of the urinary bladder and because there is no definitive test to identify IC / PBS, doctors must rule out other treatable conditions before considering a diagnosis of IC / PBS. The most common of these diseases in both genders are urinary tract infections and bladder cancer. IC / PBS is not associated with any increased risk in developing cancer. In men, common diseases include chronic prostatitis or chronic pelvic pain syndrome.

The diagnosis of IC / PBS in the general population is based on

* presence of pain related to the bladder, usually accompanied by frequency and urgency
* absence of other diseases that could cause the symptoms

Diagnostic tests that help in ruling out other diseases include urinalysis, urine culture, cystoscopy, biopsy of the bladder wall, distention of the bladder under anesthesia, urine cytology, and laboratory examination of prostate secretions.

Urinalysis and Urine Culture

Examining urine under a microscope and culturing the urine can detect and identify the primary organisms that are known to infect the urinary tract and that may cause symptoms similar to IC / PBS. A urine sample is obtained either by catheterization or by the "clean catch" method. For a clean catch, the patient washes the genital area before collecting urine "midstream" in a sterile container. White and red blood cells and bacteria in the urine may indicate an infection of the urinary tract, which can be treated with an antibiotic. If urine is sterile for weeks or months while symptoms persist, the doctor may consider a diagnosis of IC / PBS.

Culture of Prostate Secretions

Although not commonly done, in men, the doctor might obtain prostatic fluid and examine it for signs of a prostate infection, which can then be treated with antibiotics.

Cystoscopy Under Anesthesia With Bladder Distention

The doctor may perform a cystoscopic examination in order to rule out bladder cancer. During cystoscopy, the doctor uses a cystoscope-an instrument made of a hollow tube about the diameter of a drinking straw with several lenses and a light-to see inside the bladder and urethra. The doctor might also distend or stretch the bladder to its capacity by filling it with a liquid or gas. Because bladder distention is painful in patients with IC / PBS, they must be given some form of anesthesia for the procedure.

The doctor may also test the patient's maximum bladder capacity-the maximum amount of liquid or gas the bladder can hold. This procedure must be done under anesthesia since the bladder capacity is limited by either pain or a severe urge to urinate.

Biopsy

A biopsy is a tissue sample that can be examined under a microscope. Samples of the bladder and urethra may be removed during a cystoscopy. A biopsy helps rule out bladder cancer.

Future Diagnostic Tools

Researchers are investigating and validating some promising biomarkers such as anti-proliferative factor (APF), some cytokines, and other growth factors. These might provide more reliable diagnostic markers for IC and lead to more focused treatment for the disease.

What are the treatments for IC / PBS?

Scientists have not yet found a cure for IC / PBS, nor can they predict who will respond best to which treatment. Symptoms may disappear without explanation or coincide with an event such as a change in diet or treatment. Even when symptoms disappear, they may return after days, weeks, months, or years. Scientists do not know why.

Because the causes of IC / PBS are unknown, current treatments are aimed at relieving symptoms. Many people are helped for variable periods by one or a combination of the treatments. As researchers learn more about IC / PBS, the list of potential treatments will change, so patients should discuss their options with a doctor.

Bladder Distention

Many patients have noted an improvement in symptoms after a bladder distention has been done to diagnose IC / PBS. In many cases, the procedure is used as both a diagnostic test and initial therapy.

Researchers are not sure why distention helps, but some believe that it may increase capacity and interfere with pain signals transmitted by nerves in the bladder. Symptoms may temporarily worsen 24 to 48 hours after distention, but should return to predistention levels or improve within 2 to 4 weeks.

Bladder Instillation

During a bladder instillation, also called a bladder wash or bath, the bladder is filled with a solution that is held for varying periods of time, averaging 10 to 15 minutes, before being emptied.

The only drug approved by the U.S. Food and Drug Administration (FDA) for bladder instillation is dimethyl sulfoxide (DMSO, RIMSO-50). DMSO treatment involves guiding a narrow tube called a catheter up the urethra into the bladder. A measured amount of DMSO is passed through the catheter into the bladder, where it is retained for about 15 minutes before being expelled. Treatments are given every week or two for 6 to 8 weeks and repeated as needed. Most people who respond to DMSO notice improvement 3 or 4 weeks after the first 6- to 8-week cycle of treatments. Highly motivated patients who are willing to catheterize themselves may, after consultation with their doctor, be able to have DMSO treatments at home. Self-administration is less expensive and more convenient than going to the doctor's office.

Doctors think DMSO works in several ways. Because it passes into the bladder wall, it may reach tissue more effectively to reduce inflammation and block pain. It may also prevent muscle contractions that cause pain, frequency, and urgency.

A bothersome but relatively insignificant side effect of DMSO treatments is a garlic-like taste and odor on the breath and skin that may last up to 72 hours after treatment. Long-term treatment has caused cataracts in animal studies, but this side effect has not appeared in humans. Blood tests, including a complete blood count and kidney and liver function tests, should be done about every 6 months.

Oral Drugs
Pentosan polysulfate sodium (Elmiron)

This first oral drug developed for IC was approved by the FDA in 1996. In clinical trials, the drug improved symptoms in 30 percent of patients treated. Doctors do not know exactly how it works, but one theory is that it may repair defects that might have developed in the lining of the bladder.

The FDA-recommended oral dosage of Elmiron is 100 mg, three times a day. Patients may not feel relief from IC pain for the first 2 to 4 months. A decrease in urinary frequency may take up to 6 months. Patients are urged to continue with therapy for at least 6 months to give the drug an adequate chance to relieve symptoms.

Elmiron's side effects are limited primarily to minor gastrointestinal discomfort. A small minority of patients experienced some hair loss, but hair grew back when they stopped taking the drug. Researchers have found no negative interactions between Elmiron and other medications.

Elmiron may affect liver function, which should therefore be monitored by the doctor.

Because Elmiron has not been tested in pregnant women, the manufacturer recommends that it not be used during pregnancy, except in the most severe cases.

Other oral medications

Aspirin and ibuprofen may be a first line of defense against mild discomfort. Doctors may recommend other drugs to relieve pain.

Some patients have experienced improvement in their urinary symptoms by taking tricyclic antidepressants (amitriptyline) or antihistamines. Amitriptyline may help to reduce pain, increase bladder capacity, and decrease frequency and nocturia. Some patients may not be able to take it because it makes them too tired during the day. In patients with severe pain, narcotic analgesics such as acetaminophen (Tylenol) with codeine or longer acting narcotics may be necessary.

All drugs-even those sold over the counter-have side effects. Patients should always consult a doctor before using any drug for an extended amount of time.

Transcutaneous Electrical Nerve Stimulation

With transcutaneous electrical nerve stimulation (TENS), mild electric pulses enter the body for minutes to hours two or more times a day either through wires placed on the lower back or just above the pubic area, between the navel and the pubic hair, or through special devices inserted into the vagina in women or into the rectum in men. Although scientists do not know exactly how TENS relieves pelvic pain, it has been suggested that the electrical pulses may increase blood flow to the bladder, strengthen pelvic muscles that help control the bladder, or trigger the release of substances that block pain.

TENS is relatively inexpensive and allows the patient to take an active part in treatment. Within some guidelines, the patient decides when, how long, and at what intensity TENS will be used. It has been most helpful in relieving pain and decreasing frequency in patients with Hunner's ulcers. Smokers do not respond as well as nonsmokers. If TENS is going to help, improvement is usually apparent in 3 to 4 months.

Diet

There is no scientific evidence linking diet to IC / PBS, but many doctors and patients find that alcohol, tomatoes, spices, chocolate, caffeinated and citrus beverages, and high-acid foods may contribute to bladder irritation and inflammation. Some patients also note that their symptoms worsen after eating or drinking products containing artificial sweeteners. Patients may try eliminating various items from their diet and reintroducing them one at a time to determine which, if any, affect their symptoms. However, maintaining a varied, well balanced diet is important.

Smoking

Many patients feel that smoking makes their symptoms worse. How the by-products of tobacco that are excreted in the urine affect IC / PBS is unknown. Smoking, however, is the major known cause of bladder cancer. Therefore, one of the best things smokers can do for their bladder and their overall health is to quit.

Exercise

Many patients feel that gentle stretching exercises help relieve IC / PBS symptoms.

Bladder Training

People who have found adequate relief from pain may be able to reduce frequency by using bladder training techniques. Methods vary, but basically patients decide to void (empty their bladder) at designated times and use relaxation techniques and distractions to keep to the schedule. Gradually, patients try to lengthen the time between scheduled voids. A diary in which to record voiding times is usually helpful in keeping track of progress.

Surgery

Surgery should be considered only if all available treatments have failed and the pain is disabling. Many approaches and techniques are used, each of which has its own advantages and complications that should be discussed with a surgeon. Your doctor may recommend consulting another surgeon for a second opinion before taking this step. Most doctors are reluctant to operate because the outcome is unpredictable: Some people still have symptoms after surgery.

People considering surgery should discuss the potential risks and benefits, side effects, and long- and short-term complications with a surgeon and with their family, as well as with people who have already had the procedure. Surgery requires anesthesia, hospitalization, and weeks or months of recovery. As the complexity of the procedure increases, so do the chances for complications and for failure.

To locate a surgeon experienced in performing specific procedures, check with your doctor.

Two procedures-fulguration and resection of ulcers-can be done with instruments inserted through the urethra. Fulguration involves burning Hunner's ulcers with electricity or a laser. When the area heals, the dead tissue and the ulcer fall off, leaving new, healthy tissue behind. Resection involves cutting around and removing the ulcers. Both treatments are done under anesthesia and use special instruments inserted into the bladder through a cystoscope. Laser surgery in the urinary tract should be reserved for patients with Hunner's ulcers and should be done only by doctors who have had special training and have the expertise needed to perform the procedure.

Another surgical treatment is augmentation, which makes the bladder larger. In most of these procedures, scarred, ulcerated, and inflamed sections of the patient's bladder are removed, leaving only the base of the bladder and healthy tissue. A piece of the patient's colon (large intestine) is then removed, reshaped, and attached to what remains of the bladder. After the incisions heal, the patient may void less frequently. The effect on pain varies greatly; IC / PBS can sometimes recur on the segment of colon used to enlarge the bladder.

Even in carefully selected patients-those with small, contracted bladders-pain, frequency, and urgency may remain or return after surgery, and patients may have additional problems with infections in the new bladder and difficulty absorbing nutrients from the shortened colon. Some patients are incontinent, while others cannot void at all and must insert a catheter into the urethra to empty the bladder.

A surgical variation of TENS, called sacral nerve root stimulation, involves permanent implantation of electrodes and a unit emitting continuous electrical pulses. Studies of this experimental procedure are now under way.

Bladder removal, called a cystectomy, is another, very infrequently used, surgical option. Once the bladder has been removed, different methods can be used to reroute the urine. In most cases, ureters are attached to a piece of colon that opens onto the skin of the abdomen. This procedure is called a urostomy and the opening is called a stoma. Urine empties through the stoma into a bag outside the body. Some urologists are using a second technique that also requires a stoma but allows urine to be stored in a pouch inside the abdomen. At intervals throughout the day, the patient puts a catheter into the stoma and empties the pouch. Patients with either type of urostomy must be very careful to keep the area in and around the stoma clean to prevent infection. Serious potential complications may include kidney infection and small bowel obstruction.

A third method to reroute urine involves making a new bladder from a piece of the patient's colon and attaching it to the urethra. After healing, the patient may be able to empty the newly formed bladder by voiding at scheduled times or by inserting a catheter into the urethra. Only a few surgeons have the special training and expertise needed to perform this procedure.

Even after total bladder removal, some patients still experience variable IC / PBS symptoms in the form of phantom pain. Therefore, the decision to undergo a cystectomy should be made only after testing all alternative methods and after seriously considering the potential outcome.

Are there any special concerns?
Cancer

There is no evidence that IC / PBS increases the risk of bladder cancer.
Pregnancy

Researchers have little information about pregnancy and IC / PBS but believe that the disorder does not affect fertility or the health of the fetus. Some women find that their IC / PBS goes into remission during pregnancy, while others experience a worsening of their symptoms.
Coping

The emotional support of family, friends, and other people with IC / PBS is very important in helping patients cope. Studies have found that patients who learn about the disorder and become involved in their own care do better than patients who do not. See the Interstitial Cystitis Association of America's website under "Support Groups" to find a group near you.
Hope Through Research

Although answers may seem slow in coming, researchers are working to solve the painful riddle of IC / PBS. Some scientists receive funds from the Federal Government to help support their research, while others receive support from their employing institution, drug pharmaceutical or device companies, or patient support associations.

NIDDK's investment in scientifically meritorious IC / PBS research across the country has grown considerably since 1987. The Institute now supports research that is looking at various aspects of IC / PBS, such as how the components of urine may injure the bladder and what role organisms identified by nonstandard methods may have in causing IC / PBS. In addition to funding research, NIDDK sponsors scientific workshops where investigators share the results of their studies and discuss future areas for investigation.
Clinical Research Network

The Interstitial Cystitis Clinical Research Network (ICCRN) is a product of two NIDDK programs: the Interstitial Cystitis Database (ICDB) Study and the Interstitial Cystitis Clinical Trials Group (ICCTG). Established in 1991, the ICDB was a five-year prospective cohort study of more than 600 men and women with symptoms of urinary urgency, frequency, and pelvic pain. The study described the longitudinal changes of urinary symptoms, the impact of IC on quality of life, treatment patterns, and the relationship between bladder biopsy findings and patient symptoms. The ICCTG was established in 1996 as a followup to the ICDB study. The clinical trials group developed two randomized, controlled clinical trials of promising therapies, one using oral therapies-pentosan polysulfate sodium (Elmiron) and hydroxyzine hydrochloride (Atarax)- and the other administering intravesical treatment using Bacillus Calmette-Guérin (BCG). BCG is a vaccine for tuberculosis that stimulates the immune system and may have an effect on the bladder. The ICCTG also developed and conducted ancillary studies of various biomarkers such as heparin-binding-growth-factor-like-growth-factor (HB-EGF) and anti-proliferative factor (APF).

In 2003, the ICCTG became the Interstitial Cystitis Clinical Research Network (ICCRN), which is conducting additional clinical trials, either sequentially or concurrently, over a second five-year period. Ancillary studies will be developed and conducted in conjunction with the trials. One of these trials is studying the effectiveness of amitriptyline (Elavil) in treating painful bladder syndrome, which includes IC. Amitriptyline has FDA approval for the treatment of depression, but researchers believe the drug may work to block nerve signals that trigger pain in the bladder and may also decrease muscle spasms in the bladder, helping to cut both pain and frequent urination. Participants in the trial will be randomly assigned to take up to 75 milligrams of amitriptyline or a placebo each day for 14 to 26 weeks.
Suggested Reading

The materials listed below may be found in medical libraries, in many college and university libraries, through interlibrary loan in most public libraries, and at bookstores. Items are listed for information only; inclusion does not imply endorsement by NIH.
Articles and Book Chapters

Keay SK, Warren JW. Is interstitial cystitis an infectious disease? International Journal of Antimicrobial Agents, 2002, 19(6):480-3.

The Interstitial Cystitis Clinical Trials Group. A randomized controlled trial of intravesical bacillus Calmette-Guerin for treatment of refractory interstitial cystitis. Journal of Urology, 2005, 173(4):1186-91.

The Interstitial Cystitis Clinical Trials Group. A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis. Journal of Urology, 2003, 170(3):810-15.

Books and Booklets

Moldwin RM. Interstitial cystitis survival guide: your guide to the latest treatment options and coping strategies. Oakland, CA: New Harbinger Publications, Inc.; 2000. (Available by calling 1-800-HELP-ICA.)

Sandler GG, Sandler A. Patient to patient: managing interstitial cystitis and overlapping conditions. New Orleans, LA: Bon Ange LLC; 2000.

Sant G, ed. Interstitial cystitis. Philadelphia: Lippincott-Raven; 1997.

The U.S. Government does not endorse or favor any specific commercial product or company. Trade, proprietary, or company names appearing in this document are used only because they are considered necessary in the context of the information provided. If a product is not mentioned, the omission does not mean or imply that the product is unsatisfactory.