What is the physiological reason we feel "empty" when were depressed?

Answer 1

The physiological reason is an imbalance of the neurotransmitters seratonin, norepinephrine, and dopamine. The cure is to get your body as healthy as you can, get some therapy, and learn how to be positive. Here are some helpful links:
http://www.nealhendrickson.com/mcdougall/2004nl/040300pudepression.htm
http://www.phifoundation.org
http://www.seekwellness.com/bookstore/books/book65.htm
http://moodgym.anu.edu.au/
My story:
http://www.geocities.com/seabulls69/AntidepressantThatWorks.html

Answer 2

The reason we feel "empty" during depression is because we feel the need to be whole again, we have that craving to be happy once more, but we can't seem to find what makes us totally happy. Whether it's through madness or even sanity, (or the lack of it), we still want to be happy even when we're not. Only we can determine that.

Answer 3

For a biochemical explanation, doctors think it is the lack of serotonin that can make us feel that way. It depends on why you are depressed, though---chemical imbalance, or if you have actually suffered a loss.

Answer 4

We have a need that needs to be filled, or a loss, therefore the "empty" feeling.

Answer 5

Okay, alot of times, it could stem, from being alone too much..Or, from thinking to much about everything thats wrong in your world around you... Or, from chemical imbalance, or PMS, or Menopause, or Perimenopause, or the loss, of a loved-one.... It could be your just not "Happy" with your life, period.. I have gone through Depression, for many years,and I finally "Nailed" what mine was caused from, #1 Being the youngest of six kids, and being ingored all of my life by all of them including my parents. #2.Then some of it, was from my "Horribly Abusive" childhood, from my step-mother... And because she always made me and my closest sister, feel and think we weren't even worth the "Air she had to breathe" we felt like that, even into "Adulthood"... Everyone deals with their Depression, differently... My sister, is an "Over-Acheiver" because, I think she's over compensating for all those horrible things our step-mom, said to us.. Plus, she's an alcoholic, and Belemic, and very overweight, but she comes off like nothing bothers her, and she wont allow anything, or anyone to get in her way of "Happiness" see my sister, holds in all in internally, without knowing on the outside you can see she's got "Issues".. She's in "Big-Time" denial, that our childhood effected her in anyway.. Where as I have a tendecy to "Recluse"... See my step-mom, used to keep us locked-up in our room for years, and even if she allowed us to come out, we were so afraid of her, we didn't want to come out, not even to eat the "seldom-dinners" we were allowed.. She starved us, she beat us almost on a daily basis.. And tried to kill me and my sister both twice! We went to live with her & my dad, at "Crucial-Ages" they say the first 5 years of a childs life is when their molding of who they'll become when they grow-up... Its thee most important years for a Parent to show their children Love, and guidance, and all the attention, they can.. a little bit of discipline, like taking something away from them or the corner, works for me, with my own, when they were younger.. anything but spanking or hitting of any kind during these years, unless they are outright, really bad, then a say a good hard spanking on the but, twice, is suffice.. then make them lay on their bed to think about what they've done to deserve that spankin'.. But, see because my step-mom, was like the key holder of our freedom, I have a tendecy, to subconciously stay in my house, and like "Punish-myself" now that I'm a mother.. Because, I refer being involved with my own children, just the same way I did, when I was a child.. And shut out the "Outside World" as we know it... which in retrospect was all I was taught.. Its sad when your own children have less fears, than you do, or they can be & feel "Free" to go and socialize, and do anything better than their parent do. And being locked-up in my apartment after being "Hit by a car" in 2001, made it very easy to regress back to my old "Comfort-Zone" staying locked up in the house!! Not good!! So, I decided Satan wasn't going to totally take away my whole entire past,present, and my future, anymore!! I went and enrolled in school, and I now see a therapist, who's really down-to-earth... And I feel like I have "Me" time, now.. And I'm nowhere near, what I used to be, Depression-wise.. Sometimes we have to make ourselves go for a walk, and pretend to be happy, and or share a "Smile" even when we dont feel like doing it, and eventually we will feel happy.. Busy hands are happy hands. And believe me, that expression holds so "True".. Idle hands are the devil's workshop... See Satan roams like the earth like a "Roaring Lion, seeking whom he can devour.. And he'll use depression, drugs,alcohol or anything he can to destroy us all, because, he "Jealous" of all of us, cuz we were made in God's image.. He hates every single one of us!! And will use anything he can to keep us all messed-up anyway he can!! So you know what I say to that! Get under my feet, Satan, you are not going to steal my Joy, today!! And No weapons shall form against me, to prosper! By the Blood of Jesus, be gone out of my day, Satan!! And if you continue to pray this, and or join a good Pentecostal church , they willl pray for you!! I have to go check my laundry, now! Dont allow Satan to steal your Joy, anymore!! His days are numbered anyway, why let him have the satisfaction of knowing he ruined another person's day?! NOT!! God Bless you, and I'll say a prayer for you, for Satan to get his filthy hands up off of you & your emotions, okay.. take care, and make a new start today, that you are not going to allow satan to defeat you anymore!! Under your feet with him!! Smile, Jesus Loves, you like no other!! Christy...