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Tumor necrosis factor alpha (TNF-alpha), which is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggest a neuroprotective function of this cytokine.

Ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. Aberrant forms of this protein has been noticed in patients with Alzheimer's and Down syndrome.

Nucleolin (NCL), a nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus.

Outer dense fiber of sperm tails 1 (Odf1). The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility.

Perilipin coats lipid storage droplets in fat cells (adipocytes), thereby protecting them until they can be broken down by hormone-sensitive lipase. Perilipin is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis.

2006-09-19 12:55:14 · answer #1 · answered by Anonymous · 0 0

a million) PFK-a million (phosphofructokinase): fee proscribing step of glycolysis 2) Isocitrate dehydrogenase: fee-proscribing step of the Kreb's cycle 3) Cytochrome c oxidase: first enzyme complicated of the electron transport chain 4) Lactate dehydrogenase: conversion between lactate and pyruvate in anaerobic respiration 5) Pepsin: the widespread enzyme on your abdomen that breaks down proteins

2016-10-17 07:22:59 · answer #2 · answered by Anonymous · 0 0

Enzymes are proteins that speed up chemical reactions they do so by reducing activation energy needed, they are also called catalysts

2006-09-19 13:59:29 · answer #3 · answered by Anonymous · 0 1

(1) Lactic dehydrogenase-converting pyruvate to lactic acid-after a severe excercise, it accumaltes in muscles.
(2) Acetyl choline estearase-converts acetyl choline to acetate and choline-In epilepsy it is poured in large amounts resulting in seizures
(3)Invertase converts Sugar (Sucrose) to glucose and fructose.
(4)Pepsin breaks proteins at specific sites.
(5) Amylase converts Amylose(Starch) to glucose

2006-09-19 13:04:50 · answer #4 · answered by ssrvj 7 · 0 0

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