Very difficult question about genetics, help!?

Question

I was talking to a person who says they are a woman trapped in a mans body. "She" says that she was born with xyx chromosomes instead of just xx or xy. She says that while developing as an embryo in the womb, it caused the hormones to change her body into a boy, but not her mind. I know there are really people who feel like this, and I'm not out to debate about how right or wrong it is, or whatever. what i want to know, is if its possbile for that scenario to happen with ones genes and development as an embryo. how do 3 gender chromosomes get passed instead of 2? how does that effect development? is it a real genetic malfunction? please only educated answers, im looking for fact, not opinion. thankyou.

this person has no extra parts, they were born completly as a boy in the physical sense, but has always felt like a girl in their heart and mind, and truly believes that they are a product of genetic malfunction, what i want to know is scientific fact, whether its possible and how it happens

Answer 1

well it is very possible, and there are many reasons for this is the most commen are that in female ovaries when eggs divide proper division of chromosomes doesn't take place, and it can lead to eggs with 2 x chromosomes rather than one(the older the female more the chances of this happening), when this abnormal egg fuses with a normal y sperm xxy is produced. other combinations that could occur are xxx,(these women have pronounced female characteristics), some times a single x has also been witnessed (these cells develop into a female)
one solution to this problem is to get a sex change operation, but this person should talk to a doctor before taking any decision.
There are other explanations for the problems this person is going through, some times genetically normal boys are exposed to high level of female hormones in the womb, and can develop into a physically normal male, but have psychological tilting to wards a female.
Some times it could even be the environment, boys living in a predominantly female environment, (living with female siblings) can some times face this problem.

Answer 2

Hi;

Sex chromosome anomolies are fairly common. If one has an XXY sex chromosome complement, this is called Klinefelter's syndrome. The presence of a Y chromosome is pretty much all that is needed for a fetus to go down the "male" pathway, so Klinfelter's males look,,,male! However, there is very little evidence to support the idea that this has much to do with any kind of sexual identity or sexual preference peculiarities. It seems clear that psychological elements are more important here. Even if there are genetic influences on genetic identity and sexual orientation, I have never heard of this being related to Klinefelter's. These anomolies occur due to "non-discjunction" of the sex chromosomes during the cell division process that makes sperm and eggs. This simply means that the chromosomes fail to separate, so a sperm cell, for example, which should contain just a Y chromsome, ends up having both an X and a Y; when it fertilizes the egg (which has one X), you get the XXY individual. By the way, one of the X chromosomes is "inactivated", as it is in normal women. (The proper dose of the X chromosome is one copy).

Hope this helps!

Answer 3

As is true in the case of the autosomes (the non-sex-linked chromosmes), there routinely are cases where there is a "non-disjunction" during meiosis (during germ cell formation) and a particular germ cell can end up with two functional sex chromosomes. In the case of autosomes the most widely recognized case of non-disjunction occurs when children are born with Down's syndrome, a trisomy of chromosome 21.

In the case of male XXY, this used to be referred to as Klinefelter's syndrome, after the Physician in Boston who first described it. But we now know that many of the people with XXY show no outward obvious developmental anomalies so the name "XXY male" has become more commonplace.

Since there are no absolute developmental anomalies that occur when an embryo is XXY, it is difficult to understand when the differences arise for those embryos that end up showing some characteristics of the original syndrome.

Answer 4

It is possible 2 b born with an extra sex chromosome. This results from a phenomenon known as non-disjunction, and this occurs during the process of cell division. The resultant abnormal gamete, when unites with the gamete of the opposite sex, can lead to such abnormality. U can have xxy,xxx or others.These lead 2 physical & mental issues, but i ain't positive about feelin u r in the wrong body.

Answer 5

It is possible to have an anomalous sex chromosome. It in fact occurs in 1 in every 1000 male births being one of the most common genetic abnormalities. It is clear that there are many physical manifestations of this disorder but whether this extends to psychological problems may very well be possible.

Answer 6

It is possible to get errors while passing on chromosomes and get weird combinations; XXY, X, XXX, XYY, XXY etc...

some of them die during birth, some live on to be sterile or mentally incompacitated. Some are fine but their offspring might have problems mentioned above.

However, I dont get the qualifications of feeling like a girl. Wanting to play with dolls, buy skirts and bras, painting his nails are not reasons as they are all social constructs of what a girl should do.

Make sure its a scientific reason why he feels like a girl (breasts or something, no adams apple etc)

Answer 7

There are essentially three difficulties with studying the genetics of human populations : 1. Low biotic potential (relatively long maturity period creates wide generations, and the number of offspring per couple is comparatively low) Human women may have as few as four children throughout their fertile years, and these children will take an average of 16-20 years to reach adulthood. Compare this with rabbits, who can be sexually active as early as three months of age, and produce a litter of 4 to 10 baby bunnies about every 31 days. 2) Little control over breeding - it is not customary in most societies to pair adults for breeding as scientists do with flies and mice. 3) Complexity - Human traits are inherited polygenically, with many genes for one trait. There are continuous and often extreme variations, for example in such traits as physique, skin color, and intelligence...!!

Answer 8

I don't think it is possible. Some people develop some characters of alternate sex, but that doesn't mean they have an extra chromosome.

Answer 9

the parents had sex together and after one of them had another sex with a different person and it worked out for the three people and that means one of them is not honest with the other partner

Answer 10

i don't think its possible i think its all in your mind the mind is a very powerful thing