What is Adenocarcinoma?

Question

My dad was diagonised that his prostate gland was enlarged,biopsy result stated that 3+4 stages were seen,there was also 5th stage.how serious is this,will it affect his life span?

Answer 1

Sorry to hear about your dad. Best wishes to him.

Prostatic Adenocarcinoma

Adenocarcinoma of the prostate is common. It is the most common non-skin malignancy in elderly men. It is rare before the age of 50, but autopsy studies have found prostatic adenocarcinoma in over half of men more than 80 years old. Many of these carcinomas are small and clinically insignificant. However, some are not, and prostatic adenocarcinoma is second only to lung carcinoma as a cause for tumor-related deaths among males.

Men with a higher likelihood of developing a prostate cancer (in the U.S.) include those of older age, black race, and family history. Those with an affected first-degree relative have double the risk.

Prostate cancers may be detected by digital examination, by ultrasonography (transrectal ultrasound), or by screening with a blood test for prostate specific antigen (PSA). None of these methods can reliably detect all prostate cancers, particularly the small cancers.

PSA is a glycoprotein produced almost exclusively in the epithelium of the prostate gland. The PSA is normally less than 4 ng/mL (normal ranges vary depending upon which assay is used). A mildly increased PSA (4 to 10 ng/mL) in a patient with a very large prostate can be due to nodular hyperplasia, or to prostatitis, rather than carcinoma. A rising PSA (more than 0.75 ng/mL per year) is suspicious for prostatic carcinoma, even if the PSA is in the normal range. Transrectal needle biopsy, often guided by ultrasound, is useful to confirm the diagnosis, although incidental carcinomas can be found in transurethral resections for nodular hyperplasia.

Men who have findings suspicious for carcinoma on digital rectal examination and a PSA of <4 ng/mL have a probability of cancer of at least 10%, while those with PSA levels from 4 to 10 ng/mL have a 25% probability. Men with PSA's above 10 ng/mL have a >50% likelihood of having a prostate cancer.

Prostatic adenocarcinomas are composed of small glands that are back-to-back, with little or no intervening stroma. Cytologic features of adenocarcinoma include enlarged round, hyperchromatic nuclei that have a single prominent nucleolus. Mitotic figures suggest carcinoma. Less differentiated carcinomas have fused glands called cribriform glands, as well as solid nests or sheets of tumor cells, and many tumors have two or more of these patterns. Prostatic adenocarcinomas almost always arise in the posterior outer zone of the prostate and are often multifocal.

Prostatic adenocarcinomas are usually graded according to the Gleason grading system based on the pattern of growth. There are 5 grades (from 1 to 5) based upon the architectural patterns. Adenocarcinomas of the prostate are given two grade based on the most common and second most common architectural patterns. These two grades are added to get a final grade of 2 to 10. The stage is determined by the size and location of the cancer, whether it has invaded the prostatic capsule or seminal vesicle, and whether it has metastasized.

The grade and the stage correlate well with each other and with the prognosis. The prognosis of prostatic adenocarcinoma varies widely with tumor stage and grade. Cancers with a Gleason score of <6 are generally low grade and not aggressive. Advanced prostatic adenocarcinomas typically cause urinary obstruction, metastasize to regional (pelvic) lymph nodes and to the bones, causing blastic metastases in most cases. Metastases to the lungs and liver are seen in a minority of cases.

Answer 2

Adenocarcinoma is a form of carcinoma that originates in glandular tissue. To be classified as adenocarcinoma, the cells don't necessarily need to be part of a gland, as long as they have secretory properties. This form of carcinoma can occur in some higher mammals, including humans. It can first present as an adenoma (a glandular tumor that is benign.) It's also associated in the different types of cancer like breast cancer, colon cancer, lung cancer, prostate cancer, stomach cancer, pancreatic cancer (75-96% are Ductal cell adenocarcinoma) and cervical cancer.

Answer 3

Adenocarcinoma is a type of cancer you get when glandular tissue grows in an uncontrolled fashion. Prostate cancer is one type of glandular tissue that can give rise to adenocarcinoma.

Your dad's lifespan may be diminished if it is an aggressive form of cancer.

Have a look at the wikipedia site about prostate cancer.

Answer 4

adenocarcinoma is a general term for a malignant tumor, meaning it will grow back once cut out, and has potential to spread systemically and start cancer in other places of the body that previously had none

sadly, with a multiple staged tumor like what you mentioned, it is very serious and prognosis usually isn't great, but there ARE treatments for it

Answer 5

Non-small cell lung cancer involves adenocarcinoma, squamous cell and large cell cancer. Surgery is the primary option for early stages of this type. Overall, between 20 to 80% of non-small cell lung cancer can be cured by surgery, depending on the size of the tumor and whether the cancer has spread to other parts of the body.
There are four stages of non-small cell lung cancer:
Stage I lung cancer, in which the cancer is only in the lung
Stage II lung cancer, in which the cancer has spread to lymph nodes near the tumor and within the lung
Stage III lung cancer, in which the cancer is confined to the chest, but has spread beyond the lungs
Stage IV lung cancer, in which the cancer has spread from the lungs to other parts of the body, such as the brain, liver or bones
Knowing the stage of lung cancer helps the doctor set the treatment plan. The patient's medical history and condition are evaluated as part of the staging process. Tests are given to see if the patient has enough lung capacity to safely undergo surgery. Other tests, such as a bone or brain scans, may be needed to see if the tumor has spread to other parts of the body.
As with all cancers, lung cancer may be treated with surgery, chemotherapy or radiation treatments. The treatment depends on the type and extent of the cancer.

Answer 6

This means there is a cancerous cell of the glandular tissue. Usually, 3-4th stages of cancer (this and any) are fatal, especially if they are found this way and not treated in earlier stages. This doesn't sound good, and he should discuss his options with his doctor.

Answer 7

hi,adenocarcinoma is a type of tumor which is either malignant or not,this will be determined by a swab taken from injured tissue,in general i hope the best for your father and i think that treatment will be usefull in his situation.

Answer 8

its a tye of cancer...