can anyone give me a list of antifungal chemicals that can be found (and can extracted) in plants?

Question

i'm working on a science project that involves effectively killing a certain kind of fungi (we are also debating on whether or not to use Aspergillus niger or Candida albicans) that is pathogenic to human beings.

i've researched a couple of antifungal chemicals found in plants such as Eugenol (-- is this even non-toxic to the human body?), which greatly found in cloves. the problem is, it has already been done and documented before.

i need either another plant that contains that contains a great amount of that chemical (eugenol) or find some other chemical and plant altogether.

people who are in the know, much help please!

Answer 1

eugenol can be used as an antiseptic, but overdose could be quite harmful to human body [I dont know whether overdose could be lethal though]. I think eugenol is merely a general antiseptic, not specific targeting fungi but also bacteria and such.

the production of eugenol is mainly from oil industry through a series of chemical syntheses, but naturally, eugenol can be found in either clove or cinnamon [Cinnamomum verum]. However, there wont be _a great amount_ of engenol in either of the plants, say less than 1% by weight. And to obtain relatively pure eugenol, you need a series of extraction and I wont expect the yield to be high.

Antifungal drugs are very tricky since fungi, unlike bacteria, are eukaryotes like us. The basic celluar structure are nearly identical,This means it is more difficult to find a target for an antifungal medication to attack that does not also exist in the infected organism. Consequently, there are often side-effects to these drugs. Some of these side-effects can be life-threatening.
The antifungal drugs we used is normally targetting on fungal cell wall or enzymes.

Answer 2

Antifungal Chemicals