Can anyone help me here?What is the primary, secondary, tertiary and quartenary structure of the enzyme telomerase?Just a general answer will do fine...
2006-07-30 23:47:54 · 3 answers · asked by Who_am_i 1 in Science & Mathematics ➔ Biology
Telomerase is an enzyme that adds specific DNA sequence repeats ("TTAGGG" in all vertebrates) to the 3' ("three prime") end of DNA strands in the telomere regions at the ends of chromosomes. These telomeres contain condensed DNA material during replication. The enzyme is a reverse transcriptase that carries its own RNA template; this RNA is used as a template for eukaryotic DNA replication.
Human telomerase is composed of at least two sub-units, human Telomerase Reverse Transcriptase (TERT) and human Telomerase RNA (hTR or TERC). These two subunits are coded for by two different genes in the genome. The coding region of the TERT gene is 3396bp, and translates to a protein of 1131 amino acids. The polypeptide folds with TERC (451 nucleotides long), which is not translated and remains as RNA. TERT has a 'mitten' structure that allows it to wrap around the chromosome to add single-stranded telomere repeats.
TERT is a reverse transcriptase, which is a class of enzymes that creates single stranded DNA using single stranded RNA as a template. Enzymes of this class (but not TERT specifically) are utilized by scientists in the molecular biological process of Reverse Transcriptase PCR (RT-PCR), which allows the creation of several DNA copies of a target sequence using RNA as a template. TERT carries its own template around, TERC.
2006-07-31 02:01:23 · answer #1 · answered by PrAt 3 · 0⤊ 0⤋
primary structure of the enzyme would be a list of it's amino acids in a row.
secondary structure would be if it has a particular substructure like a helix or a beta strand. telomorase would be p80 or p90 protein.
tertiary would be its actual 3D shape, disulphide bonds etc. In case of telomerase it would be the protein not connected to the DNA strand
quartenary would be if the protein had several other components that join together to form a larger protein/enzyme structure... this is probably the structure telomerase takes when it is actually joined to a DNA molecule.
2006-07-31 00:02:32 · answer #2 · answered by cehelp 5 · 0⤊ 0⤋
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2016-10-01 07:13:31 · answer #3 · answered by robinette 4 · 0⤊ 0⤋