How do thiazide diuretics and loop diuretics effect glomerular filtration rates?

Question

I've looked everywhere. Someone help?

Answer 1

Both these diuretics work by decreasing GFR. The loop diuretic work by preventing reabsorbing of of Nacl, water and K. By preventing this reabsorbtion, the body will get rid of more fluid than it would in a person who is not on a diuretic. This of the two is the more potent diuretic because it effects the beginning of the entire process. But it has a shorter duration. The thiazide diuretic work by stopping the reabsorbtion of Na Cl and water by affecting the distal convoluted tubule. But by the time the DCT is reached only 10 % of NaCl remain and only 25% of water remain in the tubule. Which makes it less effective.
In conclusion Loops are more effective in decreasing GFR than thiazide. Because when fluid is lost from the body by these two diuretics (both cause decreased blood volume) the less available for filtrate hence lowering GFR.
Hope this help.

Answer 2

The main adverse effects of loop diuretics are hypokalaemia and dehydration. It is for this reason that patients are encouraged to eat a banana each day when they are on loop diuretics. Your reasoning needs to be refined further. You are familiar with the internet and you will find the answer sooner or later.

Answer 3

Glomerular Filtration Rate is effected by three things:

1. Changes in diameters of afferent or efferent arterioles affect GHP (blood pressure in the glomerular)

2. Changes in plasma protein concentration affect BCOP (glomerular capillary osmotic pressure)

3. Changes in CHP (Capsular hydrostatic pressure) may be caused by obstructions in urinary tract.

Thiazide and look diuretics probably fall under the third one. CHP affects GFR like this: a kidney stone lodged in ureter causes the GFR to decrease.

I've just learned about this too...so forgive me if I'm wordy. I hope this helped. You can always look it up

http://highered.mcgraw-hill.com/sites/0070272468/student_view0/getbodysmart.html