erythromycin metabolites?

Question

structures and mechanism

Answer 1

erythromycin (ĭrĭth'rōmī'sĭn) , any of several related antibiotic drugs produced by bacteria of the genus Streptomyces (see antibiotic). Erythromycin is most effective against gram-positive bacteria such as pneumococci, streptococci, and some staphylococci (see Gram's stain). The antibiotic also has some effect on gram-negative bacteria and some fungi. Erythromycin inhibits protein synthesis in susceptible microorganisms. It is used to treat such diseases as pneumonia caused by fungi, and streptococcus and syphilis infections, especially where the patient is allergic to penicillin.







Most of erythromycin is metabolised by demethylation in the liver. Its main elimination route is in the bile, and a small portion in the urine. Erythromycin's half-life is 1.5 hours.



Mechanism of action

Erythromycin prevents bacteria from growing, by interfering with their protein synthesis. Erythromycin binds to the 23s rRNA molecule in the 50S of the bacterial ribosome, blocking the exit of the growing peptide chain thus inhibiting the translocation of peptides.


structure

Erythromycin is a macrolide antibiotic which has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. It is also used to treat outbreaks of chlamydia, syphilis, and gonorrhea. Structurally, this macrocyclic compound contains a 14-membered lactone ring with ten asymmetric centers and two sugars (L-cladinose and D-desoamine), making it a compound very difficult to produce via synthetic methods.

Erythromycin is produced from a strain of the actinomyces Saccaropolyspora erythraea, formerly known as Streptomyces erythraeus.

Answer 2

The macrolides penetrate well into the respiratory, genitourinary, and GI tracts as well as into skin, soft tissues, and sinuses. They are only moderately (40% to 50%) protein-bound. Erythromycin and clarithromycin are mainly metabolized by the liver. The metabolites of erythromycin are excreted in the bile and urine to a small extent. Clarithromycin is metabolized to a pharmacologically active compound, 14-hydroxy clarithromycin, which undergoes renal elimination. This metabolite may be responsible for endowing clarithromycin with its greater efficacy against H influenzae, compared with erythromycin
more information if you need you can look into MACROLIDES
hope this helps

Answer 3

Whats the question?

Answer 4

yeah there are a few of them and some are active some aren't. what's the question exactly?