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uses and probably, work that has been carried out on it

2006-07-22 12:47:04 · 1 answers · asked by lamide a 1 in Science & Mathematics Chemistry

1 answers

I did an ACS journal search and came up with:

New Method for the Synthesis of Diversely Functionalized Imidazoles from N-Acylated -Aminonitriles
Zhong, Y.-L.; Lee, J.; Reamer, R. A.; Askin, D.
Org. Lett.; (Letter); 2004; 6(6); 929-931. DOI: 10.1021/ol036423y

An Expedient Route to the Tetrazole Analogues of -Amino Acids
Demko, Z. P.; Sharpless, K. B.
Org. Lett.; (Letter); 2002; 4(15); 2525-2527. DOI: 10.1021/ol020096x

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The molecule itself looks like aniline with a substiution of acetonitrile instead of one of the hydrogens. Can't you just put bromoacetontrile in a flask with aniline and reflux? I would think that the nitrogen from aniline would nucleophilically attack, kicking out HBr in the process.You might need to convert the bromine into something even more labile ... I'm not entirely sure.

2006-07-22 17:34:46 · answer #1 · answered by niuchemist 6 · 0 0

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